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Ixekizumab, a humanized IgG4 monoclonal antibody, has been approved for the treatment of moderate\u2010to\u2010severe plaque psoriasis in recent years. However, ixekizumab has not been studied in a population of patients with renal insufficiency. We report two cases of plaque psoriasis patients with renal dysfunction successfully treated with ixekizumab without dose reduction\uff0cwhich experience no side effects and does not cause further kidney injury.<\/jats:p>","DOI":"10.1111\/hdi.13185","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T03:39:31Z","timestamp":1728877171000},"page":"126-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Plaque psoriasis with renal dysfunction successfully treated with ixekizumab"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1038-6496","authenticated-orcid":false,"given":"Xinyu","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Zhongda Hospital Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Zhongda Hospital Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengbang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Zhongda Hospital Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,13]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"7","article-title":"Current knowledge on psoriasis and autoimmune diseases","volume":"6","author":"Ayala\u2010Fontanez N","year":"2016","journal-title":"Psoriasis (Auckl)"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-020-00409-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15945"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13622"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13467"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.07.064"},{"key":"e_1_2_6_8_1","unstructured":"Company. 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