{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T04:05:35Z","timestamp":1744430735766,"version":"3.40.4"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the efficacy and safety of locally manufactured generic sofosbuvir\u2010based direct\u2010acting antivirals in the treatment of Hepatitis C virus (HCV) infected patients on maintenance hemodialysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>We have conducted a retrospective multicenter study including patients on maintenance hemodialysis, treated with sofosbuvir\u2010based regimens between 01\/01\/2017 and 09\/30\/2021. Patients were treated for 12 or 24\u2009weeks, with sofosbuvir 400\u2009mg\u2009+\u2009ledipasvir 90\u2009mg 3\u2009times\/week, or sofosbuvir 3\u2009times\/week\u2009+\u2009daclatasvir 60\u2009mg\/d, or sofosbuvir\u2009+\u2009daclatasvir in coformulation, 3\u2009times\/week. Sustained virological response was defined as a negative HCV RNA test 12\u2009weeks after treatment. The occurrence of serious adverse events during treatment defines intolerance to treatment. Statistical analysis was performed using SPSS software (version 25).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 120 patients were treated; the mean age was 50\u2009\u00b1\u200914.17\u2009years [18\u201378], 50% were men. Twenty\u2010two patients (<jats:italic>n<\/jats:italic>\u2009=\u200922; 18.3%) were previously treated with pegylated Interferon. Genotype 1 was predominant (<jats:italic>n<\/jats:italic>\u2009=\u200968; 82%). Most of the patients (<jats:italic>n<\/jats:italic>\u2009=\u200953; 44.2%) had no significant fibrosis, and 24 (20%) had cirrhosis. The SVR rate was 93.3% (CI 95% [88.8; 97.8]) (<jats:italic>n<\/jats:italic>\u2009=\u2009112), the serious adverse events rate was 10.8% (CI 95% [0.054\u20130.166]) (<jats:italic>n<\/jats:italic>\u2009=\u200913), including 2 deaths unrelated to direct\u2010acting antivirals. Early treatment discontinuation occurred in 5.8% (<jats:italic>n<\/jats:italic>\u2009=\u20097), and a relapse in 0.8% (<jats:italic>n<\/jats:italic>\u2009=\u20091). On multivariate analysis, risk factors for serious adverse events included advanced liver fibrosis, thrombocytopenia, hypoalbuminemia, high bilirubin level, and pre\u2010treatment status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Locally manufactured generic sofosbuvir\u2010based regimens are safe and effective in maintenance hemodialysis patients. However, they should be closely monitored to manage comorbidities and complications during treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.13198","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T04:00:02Z","timestamp":1737518402000},"page":"164-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatitis C Treatment With Generic Sofosbuvir\u2010Based Regimens in Patients Undergoing Hemodialysis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9470-6603","authenticated-orcid":false,"given":"Nawal","family":"Afredj","sequence":"first","affiliation":[{"name":"Hepatology Department Centre Hospitalo Universitaire Mustapha  Algiers Algeria"},{"name":"Algiers University Faculty of Medicine  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Ouled","family":"Cheikh","sequence":"additional","affiliation":[{"name":"Hepatology Department Centre Hospitalo Universitaire Mustapha  Algiers Algeria"},{"name":"Algiers University Faculty of Medicine  Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hibatallah","family":"Belimi","sequence":"additional","affiliation":[{"name":"Hepatology Department Centre Hospitalo Universitaire Mustapha  Algiers Algeria"},{"name":"Algiers University Faculty of Medicine  Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafik","family":"Kerbouche","sequence":"additional","affiliation":[{"name":"Hepatology Department Centre Hospitalo Universitaire Mustapha  Algiers Algeria"},{"name":"Algiers University Faculty of Medicine  Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawal","family":"Guessab","sequence":"additional","affiliation":[{"name":"Hepatology Department Centre Hospitalo Universitaire Mustapha  Algiers 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