{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T04:05:36Z","timestamp":1744430736301,"version":"3.40.4"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Chronic kidney disease\u2010mineral and bone disorder (CKD\u2010MBD), is a common syndrome in end stage kidney disease (ESKD) patients, is marked by dysregulation of electrolytes and hormones, including calcium, phosphorus and parathyroid hormone (PTH). Calcimemetics are a cornerstone of PTH lowering therapy; cinacalcet, an oral calcimemetic, is the most used and typically prescribed as a daily administration, thus contributing to the high total pill burden of this population. Recent clinical trials have provided evidence that administration of cinacalcet at the dialysis unit three times a week might be a safe and effective treatment option. In this study we sought to evaluate the comparative effectiveness of cinacalcet delivered daily at\u2010home versus three times weekly in\u2010center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective matched cohort study of 2894 adult in\u2010center hemodialysis patients a between January 01, 2008 and September 30, 2022 who were started on cinacalcet for the first time (group 1: at\u2010home use or group 2: in\u2010center administration). Patients were matched (1:1) on: age, body mass index, cinacalcet dose, and baseline phosphorous, calcium, and PTH. Patients were followed until censoring (i.e., lost to follow up) or 12\u2009months after baseline, whichever occurred first. The primary outcome was achieving triple control of PTH, phosphorous, and calcium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, the patients had a median patient age of 63 (IQR: 55, 71) years, were predominately Black (41.6%) and male (56.5%), and well matched on other baseline clinical and demographic characteristics, including etiology of ESKD. Fitted proportion model results show no statistical difference between the intermittent in\u2010center or daily at home cinacalcet use group in achieving the primary outcome (triple control). The secondary outcomes of control of phosphorous or PTH, showed similar results. Calcium control was the same for 9 of 12\u2009months, and better controlled in the in\u2010center group during the remaining months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a well\u2010matched cohort, no clinical difference exists between administering cinacalcet thrice weekly in\u2010center and prescribing cinacalcet daily at\u2010home.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.13200","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:45:16Z","timestamp":1738284316000},"page":"179-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Effectiveness of Cinacalcet Taken at\u2010Home Versus Three Times Weekly In\u2010Center on Controlling Calcium, Phosphate, and Parathyroid Hormone Levels"],"prefix":"10.1111","volume":"29","author":[{"given":"Vishal","family":"Ratkalkar","sequence":"first","affiliation":[{"name":"Georgia Renal and Hypertension Care  Newnan Georgia USA"},{"name":"DaVita Patient Safety Organization  Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert","family":"Marlowe","sequence":"additional","affiliation":[{"name":"DaVita Patient Safety Organization  Denver Colorado USA"},{"name":"DaVita Clinical Research  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Sibbel","sequence":"additional","affiliation":[{"name":"DaVita Patient Safety Organization  Denver Colorado USA"},{"name":"DaVita Clinical Research  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Tentori","sequence":"additional","affiliation":[{"name":"DaVita Patient Safety Organization  Denver Colorado USA"},{"name":"DaVita Clinical Research  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Brunelli","sequence":"additional","affiliation":[{"name":"DaVita Patient Safety Organization  Denver Colorado USA"},{"name":"DaVita Clinical Research  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8065-0710","authenticated-orcid":false,"given":"Steph","family":"Karpinski","sequence":"additional","affiliation":[{"name":"DaVita Patient Safety Organization  Denver Colorado USA"},{"name":"DaVita Clinical Research  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"National Institute of Diabetes and Digestive and Kidney Diseases \u201cMineral & Bone Disorder in Chronic Kidney Disease. U.S. Department of Health and Human Services National Institutes of Health \u201d2024 https:\/\/www.niddk.nih.gov\/health\u2010information\/kidney\u2010disease\/mineral\u2010bone\u2010disorder. accessed March 6 2024."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2012.12.012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031633"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sapharm.2021.02.010"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00290109"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaa064"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17010371"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfab120"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nefroe.2015.09.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-013-0418-y"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.20203110S1158b"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3399\/BJGP.2020.0883"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.0004-2021"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-042548"},{"issue":"9","key":"e_1_2_8_16_1","article-title":"Work of Being an Adult Patient With Chronic Kidney Disease: A Systematic Review of Qualitative Studies","volume":"8","author":"Roberti J.","year":"2018","journal-title":"British Medical Journal Open"},{"issue":"12","key":"e_1_2_8_17_1","article-title":"Patient and Physician Perspectives on Treatment Burden in End\u2010Stage Kidney Disease: A Nominal Group Technique Study","volume":"12","author":"Thomas S. 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