{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T04:05:36Z","timestamp":1744430736368,"version":"3.40.4"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Data regarding the efficacy of cefepime in treating patients with <jats:styled-content style=\"fixed-case\">\n<jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n<\/jats:styled-content> infections undergoing renal replacement therapy (RRT) are limited. Therefore, we conducted a study to investigate the outcomes of recommended cefepime dosing in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective descriptive cohort study was conducted between May 2015 and December 2022 on patients diagnosed with active sepsis secondary to <jats:styled-content style=\"fixed-case\">\n<jats:italic>P. aeruginosa<\/jats:italic>\n<\/jats:styled-content> infection, requiring cefepime treatment and undergoing RRT. The primary endpoint was 30\u2010day all\u2010cause mortality, with secondary endpoints including clinical cure, microbiologic cure, infection recurrence rate, and incidence of adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 132 patients met the inclusion criteria. Of these, 81 (62.4%) were male, with a median age of 69\u2009years and a median BMI of 27\u2009kg\/m<jats:sup>2<\/jats:sup>. The most common diagnoses were pneumonia (58.3%), followed by bacteremia (18.9%). The median minimum inhibitory concentration (MIC) of cefepime for <jats:styled-content style=\"fixed-case\">\n<jats:italic>P. aeruginosa<\/jats:italic>\n<\/jats:styled-content> was 2 mcg\/mL. The median dose of cefepime was 2000\u2009mg every 12\u2009h in those undergoing continuous venovenous hemofiltration and 1000\u2009mg every 24\u2009h in those undergoing intermittent hemodialysis, with a median duration of therapy of 8\u2009days. The median Charlson Comorbidity index for survivors was 9 (8\u201311), while it was 7.5 (5.25\u20139.75) for non\u2010survivors (<jats:italic>p<\/jats:italic>\u2009=\u20090.754). The 30\u2010day survival rate was achieved in 96 patients (72.7%), the clinical cure was achieved in 58.3% of subjects, and a microbiologic cure rate of 31%. The 30\u2010day reinfection rate was 9.1%, with no documented adverse events associated with the doses used. Multivariable logistic regression analysis identified the use of vasopressors (Odds Ratio 4.6, 95% CI 1.3\u201317.1) and white blood cell count at the end of therapy (Odds Ratio 1.1, 95% CI 1.01\u20131.4) as the main predictors of all\u2010cause mortality in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that the utilized doses of cefepime in patients with <jats:styled-content style=\"fixed-case\">\n<jats:italic>P. aeruginosa<\/jats:italic>\n<\/jats:styled-content> infections undergoing RRT were effective. Larger study is needed to confirm our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.13204","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T09:29:37Z","timestamp":1739870977000},"page":"172-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of Cefepime Dosing in Patients With <i>Pseudomonas aeruginosa<\/i> Infections Undergoing Renal Replacement Therapies"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3109-0590","authenticated-orcid":false,"given":"Wasim S.","family":"El Nekidy","sequence":"first","affiliation":[{"name":"Cleveland Clinic Abu Dhabi  Abu Dhabi UAE"},{"name":"Cleveland Clinic Lerner College of Medicine, Case Western Reserve University  Cleveland Ohio 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