{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:18:31Z","timestamp":1790983111289,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20220530150412026"],"award-info":[{"award-number":["JCYJ20220530150412026"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515111112"],"award-info":[{"award-number":["2023A1515111112"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Low molecular weight heparin (LMWH), a common anticoagulant in hemodialysis, can cause the dangerous condition of heparin\u2010induced thrombocytopenia (HIT) in rare cases. The present study reviews five cases of HIT diagnosed in our center, which treats more than 400 maintenance hemodialysis patients annually over a 30\u2010year period. All five cases occurred in incident patients who were being exposed to LMWH for the first time. Treatment involved stopping LMWH and using alternative anticoagulants. Both the 4Ts score and antibody tests were used to confirm the diagnosis of HIT. Following diagnosis, close monitoring was performed for 10\u201315\u2009days in typical cases or 30\u2009days in severe cases until blood platelet levels recovered to near normal values. Our results suggest that while uncommon, HIT associated with use of LMWH can occur in hemodialysis patients, especially when patients are being exposed to this anticoagulant for the first time.<\/jats:p>","DOI":"10.1111\/hdi.13206","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T02:29:06Z","timestamp":1739845746000},"page":"242-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Low Molecular Weight Heparin\u2010Induced Thrombocytopenia: A Case Series Study of Newly Admitted Hemodialysis Patients"],"prefix":"10.1111","volume":"29","author":[{"given":"Hui","family":"Ren","sequence":"first","affiliation":[{"name":"Division of Renal Medicine Peking University Shenzhen Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liang","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine Peking University Shenzhen Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihong","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine Peking University Shenzhen Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zibo","family":"Xiong","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine Peking University Shenzhen Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5271-7079","authenticated-orcid":false,"given":"Guang","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Renal Medicine Peking University Shenzhen Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/NRR.S440182"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S404983"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-024-09245-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000040187"},{"issue":"6","key":"e_1_2_9_6_1","first-page":"10","article-title":"Chinese Expert Consensus on Heparin Induced Thrombocytopenia (2017)","volume":"98","author":"Association TpatpcocpboCM","year":"2018","journal-title":"Chinese Medical Journal (Chinese Edition)"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13330"},{"issue":"4","key":"e_1_2_9_8_1","article-title":"Unfractionated Heparin Versus Low Molecular Weight Heparins for Avoiding Heparin\u2010Induced Thrombocytopenia in Postoperative Patients","volume":"4","author":"Junqueira D. 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