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One therapy that shows promise is low density lipoprotein apheresis (LDL\u2010A). This procedure removes lipoproteins containing apolipoprotein\u2010B from the blood, thus reducing the lipid load on the renal system. LDL\u2010A also improves responsiveness to the standard FSGS therapy of corticosteroids and cyclosporine. This paper describes the current LDL\u2010A techniques, offers insight to existing clinical studies employing this therapy, and ultimately highlights LDL\u2010A as a treatment option for FSGS, post\u2010renal transplant, and nephrotic syndrome.<\/jats:p>","DOI":"10.1111\/hdi.13208","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T20:58:50Z","timestamp":1741726730000},"page":"137-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Low Density Lipoprotein Apheresis for Treatment of Focal Segmental Glomerulosclerosis"],"prefix":"10.1111","volume":"29","author":[{"given":"Maximilian","family":"Dawson","sequence":"first","affiliation":[{"name":"Northeast Ohio Medical University  Rootstown Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaarav","family":"Ghose","sequence":"additional","affiliation":[{"name":"Northeast Ohio Medical University  Rootstown Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Abdelnour","sequence":"additional","affiliation":[{"name":"Northeast Ohio Medical University  Rootstown Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8553-0361","authenticated-orcid":false,"given":"Raghav","family":"Shah","sequence":"additional","affiliation":[{"name":"Northeast Ohio Medical University  Rootstown Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adithya","family":"Sreenivas","sequence":"additional","affiliation":[{"name":"Northeast Ohio Medical University  Rootstown Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinnari","family":"Vala","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology and Pediatric Renal Transplantation, Institute of Kidney Diseases and Research Center and Dr. H L Trivedi Institute of Transplantation Sciences (IKDRC\u2010ITS) Gujarat University of Transplantation Sciences  Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidharth Kumar","family":"Sethi","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Kidney Institute, Medanta The Medicity Hospital  Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupesh","family":"Raina","sequence":"additional","affiliation":[{"name":"Akron Nephrology Associates\/Cleveland Clinic Akron General  Akron Ohio USA"},{"name":"Department of Nephrology Akron Children's Hospital  Akron Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(04)01081-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2014.05.009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05960616"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.suppl_3.68"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000200947.09626.1c"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012040389"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32833aa4ac"},{"issue":"4","key":"e_1_2_6_9_1","first-page":"404","article-title":"Monocytes and Focal Glomerulosclerosis","volume":"61","author":"Magil A. 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