{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T08:19:21Z","timestamp":1792484361788,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Parathyroidectomy is an effective intervention for patients with end\u2010stage renal disease and refractory secondary hyperparathyroidism. This study aimed to assess the long\u2010term clinical outcomes and overall quality of life of patients following parathyroidectomy in real\u2010world clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 103 patients with refractory secondary hyperparathyroidism treated with parathyroidectomy in a real\u2010world setting (51 males, age 58\u2009\u00b1\u200910\u2009years). Intact parathyroid hormone (iPTH), serum calcium, and serum phosphorus indices were compared preoperatively and at 6\u2009months, 12\u2009months, and 1\u2009year postoperatively. The proportion of patients with a &gt;\u200930% decrease in iPTH was evaluated to assess the long\u2010term treatment effect of parathyroidectomy. The EQ\u20105D\u20105L scale was utilized to evaluate the long\u2010term postoperative quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty percent of the patients included in the study had a follow\u2010up time of more than 19\u2009months (19.0 [12.0, 24.0]). The median pretreatment iPTH level was 1796.2 (905.5, 2909.8)\u2009pg\/mL, with 43.7% of patients exceeding 2000\u2009pg\/mL and 19.4% exceeding 3000\u2009pg\/mL; 19 (18%) patients had an iPTH level of \u2264\u2009800\u2009pg\/mL. The preoperative mean serum calcium level was 2.54 (0.22), 95% CI (2.44, 2.68), and the mean serum phosphorus level was 2.09 (0.48), 95% CI (1.81, 2.19). Approximately 50% of patients underwent total parathyroidectomy. The iPTH levels decreased significantly after surgery (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). At 6\u2009months postoperatively, 96.7% of the patients had a decrease in iPTH of more than 30% compared to the preoperative levels, and this percentage was 94.9% at 12\u2009months postoperatively. Mean serum calcium and phosphorus levels decreased significantly after surgery (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). More than 60% of patients achieved target serum calcium levels, and more than 40% achieved target serum phosphorus levels at 6\u2009months postoperatively, demonstrating a statistically significant increase compared to preoperative levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). No significant difference in surgical outcomes was observed between the groups with preoperative iPTH levels &gt;\u2009800 and &lt;\u2009800\u2009pg\/mL. The utilization of secondary hyperparathyroidism\u2010related medications decreased following surgical intervention. The median health utility value, as measured using the EQ\u20105D\u20105L scale, was 0.897 (0.739, 1.0), with a median VAS score of 80 (60, 90).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In clinical practice, parathyroidectomy demonstrates efficacy in reducing iPTH levels and facilitating the management of serum calcium and phosphorus levels. Moreover, this surgical intervention significantly decreases medication requirements and enhances the long\u2010term quality of life for patients postoperatively. The evidence suggests that surgical intervention may confer long\u2010term benefits to patients with refractory secondary hyperparathyroidism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.13222","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T08:30:09Z","timestamp":1743841809000},"page":"354-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Long\u2010Term Effects of Parathyroidectomy in Patients With Refractory Secondary Hyperparathyroidism"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6619-0239","authenticated-orcid":false,"given":"Liu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Nephrology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian\u2010rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"General Surgery Department &amp; Obesity and Metabolic Disease Center China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010ning","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010liang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010ning","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Nephrology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010wen","family":"He","sequence":"additional","affiliation":[{"name":"Department of Nephrology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx044"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2013.832319"},{"issue":"1","key":"e_1_2_11_4_1","first-page":"S28","article-title":"Towards Cost\u2010Effective Strategies for Treatment of Chronic Kidney Disease\u2010Mineral and Bone Disorder in Japan","volume":"13","author":"Komaba H.","year":"2009","journal-title":"Therapeutic Apheresis and Dialysis"},{"issue":"113","key":"e_1_2_11_5_1","first-page":"S1","article-title":"KDIGO Clinical Practice Guideline for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease\u2010Mineral and Bone Disorder (CKD\u2010MBD)","volume":"113","author":"Group KDIGOC\u2010MW","year":"2009","journal-title":"Kidney International. 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