{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:14:51Z","timestamp":1760573691292,"version":"build-2065373602"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cat Scratch Disease, caused by the bacterium <jats:italic>Bartonella henselae<\/jats:italic>, typically manifests with fever, headache, anorexia, weight loss, tender lymphadenopathy, and other systemic symptoms. Transmission commonly occurs through a cat scratch or bite. The clinical course varies depending on the patient's immune status, notably in individuals with conditions such as renal failure. While generally localized, Cat Scratch Disease can occasionally present as a systemic illness with diverse manifestations. This report aims to elucidate the etiology of fever of unknown origin in hemodialysis patients, focusing on the case of a 30\u2010year\u2010old female.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 30\u2010year\u2010old female patient, who routinely undergoes hemodialysis (HD) three times a week for four hours at the hemodialysis unit, was admitted to our service for further evaluation and treatment due to an infectious disease clinic presentation. She is now under close observation and management in our inpatient department.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>The patient's presenting symptoms included fever, arthralgia, night sweats, and weight loss, refractory to empirical antibiotic and broad\u2010spectrum antimicrobial therapy. Physical examination revealed lymphadenopathy and splenomegaly. Laboratory investigations demonstrated elevated C\u2010reactive protein and procalcitonin levels. Ultrasound imaging revealed reactive lymphadenopathy in multiple regions. Following the exclusion of bacterial, viral, and mycobacterial infections, including tuberculosis, a diagnosis of lymphoma was considered. However, a subsequent lymph node biopsy revealed non\u2010caseating granulomatous lymphadenitis, a histopathological finding consistent with Cat Scratch Disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Although rare, Cat Scratch Disease should be considered in the differential diagnosis of fever of unknown origin in patients with chronic kidney disease undergoing hemodialysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.13223","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T11:37:09Z","timestamp":1741693029000},"page":"419-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unexplained Fever in a Hemodialysis Patient Possibly due to Cat Scratch Disease Opportunistic Infection"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0461-1231","authenticated-orcid":false,"given":"Beyza","family":"Do\u011fan","sequence":"first","affiliation":[{"name":"Department of Nephrology University of Health Sciences City Hospital  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130brahim","family":"G\u00fcney","sequence":"additional","affiliation":[{"name":"Department of Nephrology University of Health Sciences City Hospital  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethem","family":"\u00d6mero\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Health Sciences City Hospital  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"R. A.Schwartz \u201cCat Scratch Disease (Cat Scratch Fever): Background Pathophysiology Etiology \u201d Medscape 2022."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.5177\/ntvt.2021.01.20049"},{"issue":"7","key":"e_1_2_7_4_1","first-page":"505","article-title":"Cat\u2010Scratch Disease","volume":"75","author":"Zambelli L.","year":"2020","journal-title":"Revue M\u00e9dicale de Li\u00e8ge"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42399-021-00940-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjad223"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/089686080802803s34"},{"issue":"2","key":"e_1_2_7_8_1","first-page":"99","article-title":"Cat Scratch Disease \u2013 A Neglected Zoonosis","volume":"66","author":"Hoz\u00e1kov\u00e1 L.","year":"2017","journal-title":"Epidemiologie, Mikrobiologie, Imunologie: Casopis Spolecnosti Pro Epidemiologii a Mikrobiologii Ceske Lekarske Spolecnosti JE Purkyne"},{"issue":"2","key":"e_1_2_7_9_1","first-page":"91","article-title":"Inguinal Lymphadenopathy due to \n                     Bartonella henselae","volume":"16","author":"Mancino P.","year":"2008","journal-title":"Le Infezioni in Medicina"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2013.833631"},{"key":"e_1_2_7_11_1","article-title":"Bartonella quintana\n                   Infective Endocarditis in a Homeless Man With Unexpected Positive Blood Culture","volume":"30","author":"Robert M.","year":"2022","journal-title":"ID Cases"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13823"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12235"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.4.811"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.13223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T04:41:29Z","timestamp":1760503289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.13223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,5]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/hdi.13223"],"URL":"https:\/\/doi.org\/10.1111\/hdi.13223","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"type":"print","value":"1492-7535"},{"type":"electronic","value":"1542-4758"}],"subject":[],"published":{"date-parts":[[2025,3,5]]},"assertion":[{"value":"2024-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}