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The concept of dialysis adequacy in its current form has consolidated mainly around three times weekly dialysis, which has become the worldwide accepted standard. The current drive to encourage more home hemodialysis (which is a frequent dialysis regimen) has made the lessons from daily in\u2010center hemodialysis more relevant. Frequent hemodialysis has been shown in both observational and randomized controlled studies to have some cardiovascular, mineral metabolism, and quality of life benefits. Some of what is learned from this body of literature is applicable today with increasing emphasis on home hemodialysis. This review will focus on the benefits and potential harms of daily hemodialysis to assist the practitioner in shared decision making with patients about the expected benefits and drawbacks of frequent in\u2010center dialysis and what the expected goals should be for a frequent dialysis regimen.<\/jats:p>","DOI":"10.1111\/hdi.13225","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T23:39:13Z","timestamp":1741909153000},"page":"262-274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Frequent In\u2010Center Hemodialysis: Who Can Benefit From a Frequent Dialysis Approach?"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0525-8227","authenticated-orcid":false,"given":"Steven G.","family":"Achinger","sequence":"first","affiliation":[{"name":"Department of Nephrology University of South Florida  Tampa Florida USA"},{"name":"Department of Nephrology Watson Clinic, LLP  Lakeland Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Ayus","sequence":"additional","affiliation":[{"name":"Department of Nephrology University of California, Irvine  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"44","article-title":"Daily\u2010Dialysis Programme: Indications and Results","volume":"9","author":"Bonomini V.","year":"1972","journal-title":"Proceedings of the European Dialysis and Transplant Association"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291404"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.348"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021583"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.07.015"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v32.pm9820470"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.01.001"},{"key":"e_1_2_13_9_1","first-page":"112","article-title":"Cardiac and Circulatory Abnormalities in Chronic Renal Failure","volume":"1","author":"Ayus J. 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