{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T05:13:54Z","timestamp":1760505234219,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The optimal strategy for correcting metabolic acidosis and maintaining acid\u2013base balance in hemodialysis patients remains unclear. This study aimed to evaluate and compare the effects of oral bicarbonate administration vs. increased dialysate bicarbonate concentration on predialysis serum bicarbonate levels in hemodialysis patients with metabolic acidosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single\u2010center, open\u2010label, randomized controlled trial. Adult hemodialysis patients with metabolic acidosis (serum bicarbonate\u2009&lt;\u200922\u2009mmol\/L) were randomly assigned in a 1:1:1 ratio to one of three treatment groups for 16\u2009weeks: (1) standard dialysate (32\u2009mM bicarbonate plus 3\u2009mM acetate), (2) increased dialysate bicarbonate (34\u2009mM bicarbonate plus 3\u2009mM acetate), or (3) standard dialysate with daily oral sodium bicarbonate supplementation (0.3\u20130.5\u2009mmol\/kg). Of the 75 eligible participants, 66 completed the study. The primary outcome was the difference in predialysis serum bicarbonate levels between the groups at 16\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline predialysis serum bicarbonate levels averaged approximately 19.5\u2009mmol\/L across all three groups. At 16\u2009weeks, there was no statistically significant difference in predialysis serum bicarbonate levels among the groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.701). The mean levels were 20.1 (SD 2.16)\u2009mmol\/L in the standard dialysate group, 20.5 (SD 2.04)\u2009mmol\/L in the increased dialysate bicarbonate group, and 20.8 (SD 2.61)\u2009mmol\/L in the oral supplementation group. Compared to baseline, predialysis bicarbonate levels significantly increased within the increased dialysate bicarbonate group (<jats:italic>p<\/jats:italic>\u2009=\u20090.010) and the oral supplementation group (<jats:italic>p<\/jats:italic>\u2009=\u20090.021), but not in the control (standard dialysate, no oral supplementation) group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oral or dialytic bicarbonate supplementation at the doses used in this study demonstrated equivalent effects on predialysis serum bicarbonate concentrations in acidotic hemodialysis patients. However, the amount of supplemental bicarbonate administered via either route was insufficient to achieve the target correction of acidosis (e.g., predialysis serum bicarbonate \u2265\u200922\u2009mmol\/L).<\/jats:p><\/jats:sec>","DOI":"10.1111\/hdi.13230","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T06:43:37Z","timestamp":1741934617000},"page":"310-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral Sodium Bicarbonate vs. Use of Higher Dialysate Bicarbonate in Hemodialysis Patients With Metabolic Acidosis: A Randomized Controlled Trial"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2685-3864","authenticated-orcid":false,"given":"Hoda M. M.","family":"Abdulaziz","sequence":"first","affiliation":[{"name":"Mansoura Nephrology and Dialysis Unit (MNDU), Department of Internal Medicine, Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"Sabry","sequence":"additional","affiliation":[{"name":"Mansoura Nephrology and Dialysis Unit (MNDU), Department of Internal Medicine, Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"Saleh","sequence":"additional","affiliation":[{"name":"Mansoura Nephrology and Dialysis Unit (MNDU), Department of Internal Medicine, Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada","family":"El\u2010Said","sequence":"additional","affiliation":[{"name":"Mansoura Nephrology and Dialysis Unit (MNDU), Department of Internal Medicine, Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,14]]},"reference":[{"issue":"12","key":"e_1_2_12_2_1","first-page":"S78","article-title":"Catabolism in Uremia: The Impact of Metabolic Acidosis","volume":"9","author":"Franch H. A.","year":"1998","journal-title":"Journal of the American Society of Nephrology"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.13068"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2010.00737.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.03.035"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.20748"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016070780"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V3111804"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41100-020-00302-y"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12454"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfac128"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12710"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-021-02549-x"},{"issue":"4","key":"e_1_2_12_14_1","article-title":"Correlation Between Serum and Arterial Blood Gas Bicarbonate in Patients Admitted to the Intensive Care Unit","volume":"15","author":"Kim A.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008111205"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620\u2010019\u201000656\u20105"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13330"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321461"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.711034"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000498975"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000500042"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/6657188"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.12.2633"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087195"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/08860220500461187"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000000000264"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.04.014"},{"key":"e_1_2_12_28_1","first-page":"528","article-title":"Beyond Bicarbonate: Complete Acid\u2010Base Assessment in Patients Receiving Intermittent Hemodialysis","volume":"32","author":"Marano M.","year":"2017","journal-title":"Nephrology, Dialysis, Transplantation"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2022.05.004"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.13230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T04:41:03Z","timestamp":1760503263000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.13230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,14]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/hdi.13230"],"URL":"https:\/\/doi.org\/10.1111\/hdi.13230","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"type":"print","value":"1492-7535"},{"type":"electronic","value":"1542-4758"}],"subject":[],"published":{"date-parts":[[2025,3,14]]},"assertion":[{"value":"2024-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}