{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:48:33Z","timestamp":1773254913298,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CORPF1N0022"],"award-info":[{"award-number":["CORPF1N0022"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CORPG3N0392"],"award-info":[{"award-number":["CORPG3N0392"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chronic nickel accumulation is harmful to multiple organ systems, and nickel is classified as a human carcinogen. Nevertheless, few studies have examined serum nickel concentrations in end\u2010stage kidney disease (ESKD) patients receiving chronic hemodialysis, and the relationship of serum nickel with clinical outcomes remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective observational study recruited 409 hemodialysis patients in 2019 and followed them for 18\u2009months. The patients were stratified into four quartiles, that is, &lt;\u20092.9\u2009\u03bcg\/L (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200992), 2.9\u2009\u03bcg\/L to &lt;\u20093.4\u2009g\/L (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009104), 3.4\u2009\u03bcg\/L to &lt;\u20093.9 \u03bcg\/L (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009104), and \u2265\u20093.9\u2009\u03bcg\/L (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009109), according to their serum nickel concentrations. Baseline demographic, hematologic, biochemical, dialysis\u2010related, and mortality data were obtained for analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      The mean age of the patients was 62.9\u2009\u00b1\u200911.7\u2009years. A total of 401 (98.04%) patients had elevated serum nickel concentrations, with an average level of 3.6\u2009\u00b1\u20091.3\u2009\u03bcg\/L. Higher quartiles of serum nickel were associated with longer dialysis vintage (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), higher Kt\/V values (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and higher urea removal rates (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Multivariate analysis identified albumin level and dialysis vintage as independent factors positively correlated with serum nickel concentrations (\n                      <jats:italic>R<\/jats:italic>\n                      \u2009=\u20090.163,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001;\n                      <jats:italic>R<\/jats:italic>\n                      \u2009=\u20090.212,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively). Nevertheless, no association was found between serum nickel levels and all\u2010cause mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ESKD patients on hemodialysis commonly exhibit elevated serum nickel concentrations, possibly linked to serum albumin levels and dialysis vintage. Further studies are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hdi.13235","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T08:44:40Z","timestamp":1742978680000},"page":"639-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum Nickel Concentrations in Patients Receiving Chronic Hemodialysis"],"prefix":"10.1111","volume":"29","author":[{"given":"Wen\u2010Yu","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Nephrology and Clinical Poison Center Chang Gung Memorial Hospital, Linkou Branch  Taoyuan Taiwan"},{"name":"College of Medicine, Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju\u2010Ching","family":"Yen","sequence":"additional","affiliation":[{"name":"School of Medicine College of Medicine, China Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Hao","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Clinical Poison Center Chang Gung Memorial Hospital, Linkou Branch  Taoyuan Taiwan"},{"name":"College of Medicine, Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Hung","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Clinical Poison Center Chang Gung Memorial Hospital, Linkou Branch  Taoyuan Taiwan"},{"name":"College of Medicine, Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Chung","family":"Chiu","sequence":"additional","affiliation":[{"name":"College of Medicine, Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Thoracic Medicine Chang Gung Memorial Hospital, Linkou Branch  Taoyuan 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