{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:48:26Z","timestamp":1773254906192,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Thirst distress is a common yet underexplored symptom among hemodialysis (HD) patients, with limited understanding of its impact on quality of life. This study aims to evaluate thirst perception, identify factors associated with its intensity, and examine its relationship with quality of life in a multicenter cohort of HD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional analysis utilized baseline data from the Hemodiafiltration on Physical Activity and Self\u2010Reported Outcomes: A Randomized Controlled Trial (HDFit). Participants were over 18\u2009years old from 13 dialysis units across Brazil. Thirst perception was assessed using the Dialysis Thirst Inventory (DTI) questionnaire, and health\u2010related quality of life (HRQoL) was measured with the SF\u201036 questionnaire. We compared participants with low versus high thirst perception based on the median DTI score and conducted multiple regression analysis to identify independent determinants of physical and mental HRQoL components.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>The study sample comprised 195 patients (male: 71%; median age: 54 [41\u201366] years; 29% with diabetes) from 13 dialysis centers, with chronic HD duration up to 24\u2009months. The median DTI score was 17 (14\u201322). Participants with higher thirst perception (DTI\u2009&gt;\u200917) were younger, had a higher prevalence of lower income and educational levels, and a lower prevalence of fluid overload. Multiple regression analysis, adjusted for demographic, clinical, and nutritional variables, revealed that increased thirst perception was independently associated with poorer physical and mental HRQoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a multicenter HD population, higher thirst perception was an independent determinant of diminished health\u2010related quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hdi.13271","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T02:20:03Z","timestamp":1749608403000},"page":"700-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Thirst Perception on Health\u2010Related Quality of Life in Hemodialysis Patients: A Multicenter Study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5325-6796","authenticated-orcid":false,"given":"Jyana G.","family":"Morais","sequence":"first","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica Do Paran\u00e1 (PUCPR)  Curitiba PR Brazil"},{"name":"Funda\u00e7\u00e3o Pr\u00f3 Rim  Joinville SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murilo","family":"Guedes","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana B.","family":"Barra","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care Brazil  Jaguari\u00fana SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Larkin","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care Global Medical Office  Waltham Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria E. F.","family":"Canziani","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0255-6710","authenticated-orcid":false,"given":"Roberto","family":"Pecoits\u2010Filho","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica Do Paran\u00e1 (PUCPR)  Curitiba PR Brazil"},{"name":"Arbor Research Collaborative for Health  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9936-0185","authenticated-orcid":false,"given":"Fabiana B.","family":"Nerbass","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3 Rim  Joinville SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003954"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0001862022"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-016-1327-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2009.12.026"},{"key":"e_1_2_7_6_1","first-page":"1","article-title":"Dipsogenic Factors Operating in Chronic Uremics on Maintenance Hemodialysis","volume":"1999","author":"Giovannetti S.","year":"2006","journal-title":"Nephron. 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