{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T20:21:32Z","timestamp":1788639692877,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T00:00:00Z","timestamp":1752969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T00:00:00Z","timestamp":1752969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Heparin and low\u2010molecular\u2010weight heparin (LMWH) are first\u2010line anticoagulants in hemodialysis but may trigger heparin\u2010induced thrombocytopenia (HIT), a severe immune\u2010mediated complication. Despite its clinical significance, HIT is often misdiagnosed early, increasing thromboembolic risks and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>\n                      We present a case of a 61\u2010year\u2010old male patient who developed HIT during initial hemodialysis. The patient exhibited recurrent catheter thrombosis, intermuscular venous thrombosis in the lower extremities, and progressive thrombocytopenia following LMWH administration during dialysis. The diagnosis was confirmed by IgG\u2010specific anti\u2010PF4\/heparin antibody testing. Shortly after the last dialysis session, the patient developed acute dyspnea and chest pain. Computed tomography angiography of the chest revealed pulmonary embolism. Despite aggressive intervention, the patient's condition deteriorated rapidly, with platelet counts dropping to 5\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L, culminating in a fatal outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combination of dialysis catheter thrombosis and declining platelet counts constitutes an essential early diagnostic clue for HIT in hemodialysis patients, the recognition of which could prevent fatal thromboembolic complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hdi.70011","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:24:03Z","timestamp":1753057443000},"page":"288-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fatal Pulmonary Embolism Secondary to Heparin\u2010Induced Thrombocytopenia in Hemodialysis: A Case Study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7272-1489","authenticated-orcid":false,"given":"Yan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Nephrology Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Shenzhen Clinical Research Center for Urology and Nephrology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zibo","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Nephrology Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Shenzhen Clinical Research Center for Urology and Nephrology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"He","sequence":"additional","affiliation":[{"name":"Department of Nephrology Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Shenzhen Clinical Research Center for Urology and Nephrology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Shenzhen Clinical Research Center for Urology and Nephrology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Shenzhen Clinical Research Center for Urology and Nephrology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Peking University Shenzhen Hospital  Shenzhen China"},{"name":"Shenzhen Clinical Research Center for Urology and Nephrology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018024489"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1411910"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1398381"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.5636"},{"issue":"5","key":"e_1_2_8_6_1","first-page":"303","article-title":"Pseudothrombocytopenia: Case Reports and Review of the Literature","volume":"22","author":"Huss B.","year":"1995","journal-title":"Infusionstherapie Und 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