{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T22:59:21Z","timestamp":1768949961880,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>We report the case of a 65\u2010year\u2010old Caucasian woman who presented to our emergency department following the ingestion of approximately thirty 2.5\u2009mg bisoprolol tablets. Initially stable, she rapidly developed severe bradycardia and hypotension, culminating in cardiogenic\u2013distributive shock that required intubation, aggressive vasoactive support, and advanced metabolic therapies. Due to concurrent hepatic and renal dysfunction impairing drug elimination, continuous kidney replacement therapy (CKRT) was initiated as a supportive intervention and potential drug elimination pathway. The patient's condition progressively improved, leading to complete recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In addition to describing our clinical experience, we provide a concise literature review on the use of CKRT in beta\u2010blocker poisoning, highlighting current knowledge gaps and the need for cautious interpretation in the absence of direct pharmacokinetic measurements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hdi.70012","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T07:13:15Z","timestamp":1753254795000},"page":"291-295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Management of Severe Bisoprolol Poisoning Using Continuous Kidney Replacement Therapy: A Case Report and Literature Review"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7613-9744","authenticated-orcid":false,"given":"Antonino","family":"Previti","sequence":"first","affiliation":[{"name":"Nephrology and Dialysis Unit Alto Vicentino Hospital  Santorso (VI) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Panico","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Resuscitation Alto Vicentino Hospital  Santorso (VI) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Vison\u00e0 Dalla Pozza","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Resuscitation Alto Vicentino Hospital  Santorso (VI) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Rizzato","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Resuscitation Alto Vicentino Hospital  Santorso (VI) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo Luca","family":"Lentini","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit Alto Vicentino Hospital  Santorso (VI) Italy"},{"name":"Nephrology and Dialysis Unit San Bassiano Hospital  Bassano del Grappa (VI) Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573402114666180918102735"},{"key":"e_1_2_6_3_1","unstructured":"J. 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