{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:06:13Z","timestamp":1790834773094,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Functional capacity deteriorates over time in patients on hemodialysis, which is associated with increased mortality risk. This study aimed to assess the effects of two low\u2010frequency (i.e., twice weekly) intradialytic cycling exercise training programs\u2014low\u2010 to moderate\u2010intensity continuous training (L\u2010MICT) versus moderate\u2010 to high\u2010intensity interval training (M\u2010HIIT) \u2014 on functional capacity in patients undergoing hemodialysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010seven out of sixty\u2010nine patients undergoing hemodialysis of both sexes (44 men and 23 women), aged 35\u201355\u2009years,\u00a0completed this study. Patients were randomly assigned to three groups: L\u2010MICT group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923), M\u2010HIIT group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921), and nonexercise control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923). Patients in the L\u2010MICT group performed intradialytic cycling exercise continuously at a low\u2010to moderate\u2010intensity for 20\u201330\u2009min. Patients in the M\u2010HIIT group performed 3\u2009\u00d7\u20093\u2010min moderate\u2010 to high\u2010intensity cycling exercise, separated by 4\u2010min low\u2010intensity active breaks. The intradialytic cycling programs were scheduled twice a week for 8\u2009weeks. The outcome measure was the functional capacity assessed by the 6\u2010min walk test (6MWT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      The 6\u2010min walk distance (6MWD) increased significantly in the L\u2010MICT group [\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004, the change score (\u0394) =\u200918.2\u2009meters (m)], in the M\u2010HIIT group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001, \u0394\u2009=\u200917.6\u2009m), and in the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014, \u0394\u2009=\u200911.4\u2009m) compared to baseline. However, no significant differences were found between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Low\u2010frequency intradialytic cycling training programs, either L\u2010MICT or M\u2010HIIT, twice a week for 8\u2009weeks, could similarly induce statistically significant improvements in the 6MWD in people receiving hemodialysis. Nevertheless, the 6MWD changes did not exceed the minimally detectable change previously reported in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hdi.70017","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T03:09:01Z","timestamp":1756436941000},"page":"251-257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Two Low\u2010Frequency Intradialytic Cycling Training Programs on Functional Capacity in Subjects Undergoing Hemodialysis: A Randomized Controlled Trial"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3148-885X","authenticated-orcid":false,"given":"Ahmad Mahdi","family":"Ahmad","sequence":"first","affiliation":[{"name":"Department of Physical Therapy for Cardiovascular and Respiratory Disorders, Faculty of Physical Therapy Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona Mohammed","family":"Ghareeb","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Benha University Hospital  Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Ezzat","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Benha University  Benha Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9243-2059","authenticated-orcid":false,"given":"Heba Ahmed","family":"Mousa","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy for Cardiovascular and Respiratory Disorders, Faculty of Physical Therapy Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20010871"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.03.026"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000000000000361"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2021.02.010"},{"issue":"5","key":"e_1_2_11_6_1","first-page":"726","article-title":"Beyond Statistical Significance: Clinical Interpretation of Rehabilitation Research Literature","volume":"9","author":"Page P.","year":"2014","journal-title":"International Journal of Sports Physical Therapy"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzac068"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.10.026"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.1040704"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/15438627.2022.2079983"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7857824"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/jesnt.jesnt_35_21"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2011.01302.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060513509037"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64372-y"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12764"},{"issue":"10","key":"e_1_2_11_17_1","first-page":"2364","article-title":"Comparisons of Intradialytic Exercise Versus Home\u2010Based Exercise in Hemodialysis Patients: A Narrative Review","volume":"12","author":"Lee C.\u2010L.","year":"2024","journal-title":"Biomedicine"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.72352"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41100-023-00460-9"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1687"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2023.02.1074"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsem-2019-000617"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2340\/1650197719702239298"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfad170"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20100141"},{"key":"e_1_2_11_27_1","first-page":"1","article-title":"Impact of Measurement Timing on Reproducibility of Testing Among Haemodialysis Patients","volume":"12","author":"Jim\u00e9nez A. 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