{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T22:30:13Z","timestamp":1768948213549,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>A serum transferrin (transferrin) level below 200\u2009mg\/dL has been suggested as an indicator of malnutrition in hemodialysis (HD) patients. We investigated the relationships among transferrin levels, various markers of malnutrition, and 1\u2010year mortality in this patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed transferrin, ferritin, and transferrin saturation (TSAT) five times over 1\u2009year. We also measured baseline serum albumin, C\u2010reactive protein (CRP), geriatric nutritional risk index (GNRI), Kt\/Vurea, post\u2010dialysis body composition (using bioimpedance analysis), and 1\u2010year mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>\n                      Our study included 431 HD patients (mean age: 67\u2009\u00b1\u200911\u2009years; median dialysis duration: 67 [35\u2013138]\u2009months; diabetes prevalence: 45%). Patients with baseline transferrin \u2265\u2009200\u2009mg\/dL had consistently and significantly higher transferrin concentrations throughout the study (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Compared to patients with baseline transferrin &lt;\u2009200\u2009mg\/dL (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009285), those with baseline transferrin \u2265\u2009200\u2009mg\/dL (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009146) showed significantly higher serum albumin (3.7 [3.4\u20133.9] vs. 3.4 [3.1\u20133.7]\u2009g\/dL), GNRI (95 [90\u201398] vs. 90 [85\u201395]), and lean tissue index (11.2 [9.5\u201313.3] vs. 10.3 [9.0\u201312.1]\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). Conversely, they had significantly lower TSAT (22%\u2009\u00b1\u200912% vs. 27%\u2009\u00b1\u200914%), ferritin (74\u2009\u00b1\u200979 vs. 172\u2009\u00b1\u2009148\u2009ng\/mL), and CRP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01 for all). Baseline serum albumin, Kt\/Vurea, and the presence of diabetes were significant determinants of having a baseline transferrin level \u2265\u2009200\u2009mg\/dL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Over the 1\u2010year period, 45 all\u2010cause deaths occurred among the 431 patients. Patients with baseline transferrin \u2265\u2009200\u2009mg\/dL had a significantly higher cumulative 1\u2010year survival rate (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Furthermore, baseline transferrin was a significant predictor of 1\u2010year all\u2010cause mortality in HD patients (hazard ratio: 0.99;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our findings indicate that HD patients with baseline transferrin \u2265\u2009200\u2009mg\/dL exhibit a better nutritional status than those with transferrin &lt;\u2009200\u2009mg\/dL. Moreover, baseline transferrin serves as a significant predictor for 1\u2010year mortality in HD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hdi.70018","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T03:59:39Z","timestamp":1756699179000},"page":"207-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Among Serum Transferrin Levels, Markers of Malnutrition, and Mortality in Hemodialysis Patients"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6728-5731","authenticated-orcid":false,"given":"Sonoo","family":"Mizuiri","sequence":"first","affiliation":[{"name":"Division of Nephrology Ichiyokai Harada Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Division of Nephrology Ichiyokai Harada Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Doi","sequence":"additional","affiliation":[{"name":"Division of Nephrology Ichiyokai Harada Hospital  Hiroshima Japan"},{"name":"Department of Nephrology Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiko","family":"Okubo","sequence":"additional","affiliation":[{"name":"Division of Nephrology Ichiyokai Harada Hospital  Hiroshima Japan"},{"name":"Department of Nephrology Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Morii","sequence":"additional","affiliation":[{"name":"Division of Nephrology Ichiyokai Harada Hospital  Hiroshima Japan"},{"name":"Department of Nephrology Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichiro","family":"Shigemoto","sequence":"additional","affiliation":[{"name":"Division of Nephrology Ichiyokai Harada Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuomi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Division of Nephrology Ichiyokai Harada Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuji","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hiroshima University  Hiroshima Japan"},{"name":"Ichiyokai Ichiyokai Clinic  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Masaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12103147"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.06.037"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2024.2337292"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.4638"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.316453"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11051123"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000492"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000001607"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V651319"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15112640"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.1.106"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000187980"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu049"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002585"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14163375"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.4.777"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000495999"},{"issue":"5","key":"e_1_2_9_20_1","first-page":"785","article-title":"Chronic Inflammation Increases Risk in Hemodialysis Patients","volume":"19","author":"Razeghi E.","year":"2008","journal-title":"Saudi Journal of Kidney Diseases and Transplantation"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v31.pm9469497"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.29222"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/jren.2000.16325"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.46259"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2024.2350237"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.09.031"},{"issue":"5","key":"e_1_2_9_27_1","first-page":"S11","article-title":"KDOQI Clinical Practice Guidelines and Clinical Practice Recommendation for Anemia in Chronic Kidney Disease","volume":"47","author":"KDOQI","year":"2006","journal-title":"American Journal of Kidney Diseases"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1810742"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2010.00836.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfaa117"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2017.10.014"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.114"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jorc.12234"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.07.015"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.07.029"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-024-03510-4"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.922863"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214524"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.70018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hdi.70018","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.70018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T09:39:11Z","timestamp":1768901951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.70018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,31]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/hdi.70018"],"URL":"https:\/\/doi.org\/10.1111\/hdi.70018","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,31]]},"assertion":[{"value":"2025-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}