{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T22:46:45Z","timestamp":1768949205010,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>T50 is a serum\u2010based measure of calcification propensity and a predictor of cardiovascular risk and mortality in hemodialysis (HD) patients. Cardiovascular disease is in part driven by uremic toxins. Medium cut\u2010off (MCO) dialyzers enhance the clearance of middle molecular weight (MW) uremic toxins compared to conventional dialyzers. However, the long\u2010term impact of MCO dialyzers on pre\u2010dialysis and post\u2010dialysis T50 scores remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included maintenance HD patients on low\u2010flux (LF) dialyzers. Pre\u2010 and post\u2010dialysis serum samples were collected in mid\u2010week HD sessions: first with LF dialyzers (baseline) and then 6 months after switching to MCO dialyzers. Change in T50 was analyzed for a single HD treatment under LF and MCO dialyzers, and baseline and sixth\u2010month pre\u2010dialysis T50 scores were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen patients were included. Pre\u2010 and post\u2010dialysis percent improvement in T50 for LF and MCO dialyzers were similar (85.2% [45.0, 282.7] and 56.3% [21.1, 238.6], respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.35). Pre\u2010dialysis T50 after 6 months on MCO was comparable to the baseline (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.73). Pre\u2010dialysis T50 at baseline had an inverse association with improvement in T50 after a single HD treatment (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.88; 95% CI: \u22121.18 to \u22120.57;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), and smoking had a direct association with pre\u2010dialysis T50 after 6 months of MCO treatment (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u2212172; 95% CI: \u2212287 to \u221256.8;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MCO dialyzers do not confer additional benefits in improving serum calcification propensity, compared to LF dialyzers. Our data do not support a significant contribution of middle MW uremic toxins' removal to T50 scores.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hdi.70033","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:45:23Z","timestamp":1761295523000},"page":"168-175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Medium Cut\u2010Off Dialyzers on Calcification Propensity in Hemodialysis Patients: A 6\u2010Month Prospective Pilot Study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0597-5822","authenticated-orcid":false,"given":"Berfu","family":"Korucu","sequence":"first","affiliation":[{"name":"Department of Nephrology, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology Amsterdam UMC  Amsterdam the Netherlands"},{"name":"Department of Laboratory Medicine, Laboratory of Specialized Diagnostics and Research (LGDO) Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrike","family":"Hamer","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Laboratory of Specialized Diagnostics and Research (LGDO) Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"de Jonge","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Laboratory of Specialized Diagnostics and Research (LGDO) Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serpil Muge","family":"Deger","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Faculty of Medicine Dokuz Eylul University  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Vervloet","sequence":"additional","affiliation":[{"name":"Department of Nephrology Radboud UMC  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41100-017-0094-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-018-0747-y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314187"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314941"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.122.318420"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins14090637"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18448"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304820"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9112428"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188695"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30626-z"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151508"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfz222"},{"issue":"1","key":"e_1_2_8_15_1","doi-asserted-by":"crossref","DOI":"10.1093\/ndt\/gfae069.650","article-title":"# 2124 Accuracy and Interferences in the T50 Test: Assessing the Reliability of a Novel Diagnostic Tool","volume":"39","author":"Xu J.","year":"2024","journal-title":"Nephrology, Dialysis, Transplantation"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.09.024"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04720416"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013060635"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.05.044"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2014.10.021"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.315697"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw048"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acc.2020.02.004"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv081"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.301"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324693"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512537"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw310"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.13107"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.23.061"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12999"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13060380"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169024"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-20818-z"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2020-002016"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.70033","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hdi.70033","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.70033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T09:38:39Z","timestamp":1768901919000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.70033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,24]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/hdi.70033"],"URL":"https:\/\/doi.org\/10.1111\/hdi.70033","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,24]]},"assertion":[{"value":"2025-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}