{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T10:04:38Z","timestamp":1775815478782,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      In pediatric hemodialysis patients with exhausted vascular access, managing rare pathogens like\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Ochrobactrum intermedium<\/jats:italic>\n                      <\/jats:styled-content>\n                      is challenging, often posing a dilemma between catheter removal and salvage attempts. There are few reports on the supported viability of meropenem\u2010heparin lock therapy for this purpose in pediatric patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>\n                      We present the case of a 12\u2010year\u2010old male with chronic kidney disease on hemodialysis who was admitted with sepsis attributed to her long\u2010term hemodialysis catheter.\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Ochrobactrum intermedium<\/jats:italic>\n                      <\/jats:styled-content>\n                      was isolated from all catheter lumens and blood cultures. Due to a documented history of vascular access failure, catheter salvage was the primary goal. A combined systemic antibiotic and lock therapy with meropenem and unfractionated heparin was initiated. Critically, bacteremia relapsed promptly after a planned temporary suspension of the lock therapy, while systemic antibiotics were continued. Definitive microbiological eradication was only achieved after the re\u2010initiation and completion of a 14\u2010day course of the lock therapy, resulting in full clinical recovery and long\u2010term catheter preservation. This case report suggests the potential efficacy of meropenem lock therapy as a salvage strategy for\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>O. intermedium<\/jats:italic>\n                      <\/jats:styled-content>\n                      CRBSI when catheter removal is not a viable option. The relapse upon its suspension highlights that the lock therapy itself was the critical component for eradicating the\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>O. intermedium<\/jats:italic>\n                      <\/jats:styled-content>\n                      biofilm, a feat the systemic antibiotic alone could not achieve. This approach is a viable alternative when catheter removal is not feasible.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hdi.70050","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T08:45:49Z","timestamp":1767689149000},"page":"318-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Meropenem\u2010Heparin Lock Therapy for\n                    <scp>\n                      <i>Ochrobactrum intermedium<\/i>\n                    <\/scp>\n                    Catheter\u2010Related Bloodstream Infection in a Pediatric Hemodialysis Patient: A Case Report and Literature Review"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1784-968X","authenticated-orcid":false,"given":"M\u00f4nica Cristina Dutra","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of Sao Paulo  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7923-0831","authenticated-orcid":false,"given":"Fernanda Teixeira","family":"Sillva","sequence":"additional","affiliation":[{"name":"Federal University of Alfenas  Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1993-2978","authenticated-orcid":false,"given":"Anderson Pereira","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande Do Norte, Campus Universit\u00e1rio\u2010Lagoa Nova  Natal Rio Grande do Norte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7276-9141","authenticated-orcid":false,"given":"Yeo Jim Kinoshita","family":"Moon","sequence":"additional","affiliation":[{"name":"Menino Jesus Municipal Children's Hospital  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6986-6193","authenticated-orcid":false,"given":"Jhohann Richard","family":"de Lima Benzi","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2024.1379895"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir257"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9050614"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics14050461"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13020406"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8111797"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11030377"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2018.07.009"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2008.06.009"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010021\u201006938\u20103"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.1.241\u2010244.1999"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2014.01.004"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.14648"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.05.014"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2016.09.016"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.11150\/kansenshogakuzasshi.90.129"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.3.1184\u20101186.2006"},{"issue":"2","key":"e_1_2_12_19_1","first-page":"183","article-title":"Isolation of Urease\u2010Positive \n                     Ochrobactrum intermedium\n                   in the Stomach of a Non\u2010Ulcer Dyspeptic Patient From North India","volume":"41","author":"Dharne M. 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