{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T10:04:30Z","timestamp":1775815470824,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015699","name":"Fresenius Medical Care North America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hemodiafiltration has demonstrated improved outcomes in end\u2010stage kidney disease, particularly with higher convection volumes than conventional hemodialysis. However, data on multiethnic Asian populations remain limited. This study evaluated the feasibility of achieving relatively high targeted convection volumes in hemodiafiltration in patients with end\u2010stage kidney disease in Singapore.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort analysis included 1404 patients undergoing hemodiafiltration between 2019 and 2023 at Fresenius Kidney Care clinics in Singapore using data obtained from the EuCliD database. Patients aged \u2265\u200918\u2009years and on hemodiafiltration for &gt;\u20093\u2009months were included. Multivariate regression models were used to assess the factors associated with the attainment of convection volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over 291,000 hemodiafiltration sessions were analyzed. The mean convection volumes achieved were 21.8\u2009L in post\u2010dilution and 40.8\u2009L in pre\u2010dilution mode. Higher blood flow rates and treatment durations were significantly associated with relatively high targeted convection volume (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The distribution of convection volume was similar among Chinese, Indian, and Malay patients. Ethnicity, age, and vascular access were not significant predictors. Approximately 29% of the variation in achieved convection volume was attributable to center\u2010related factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Relatively high targeted convection volume in hemodiafiltration was consistently achieved across a multiethnic cohort in Singapore. These findings support the feasibility of delivering high\u2010volume hemodiafiltration to diverse real\u2010world settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hdi.70061","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T02:59:31Z","timestamp":1771556371000},"page":"305-312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Success in Achieving Relatively High Targeted Convection Volumes in Multi\u2010Ethnic Individuals Receiving Hemodiafiltration in Singapore"],"prefix":"10.1111","volume":"30","author":[{"given":"Cindy","family":"Chan","sequence":"first","affiliation":[{"name":"Fresenius Medical Care AG Global Medical Office  Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sugandha","family":"Saxena","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care AG Global Medical Office  Gurgaon India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan Yi","family":"Cheung","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care AG Global Medical Office  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandakumar","family":"Mooppil","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care AG Global Medical Office  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Wu","sequence":"additional","affiliation":[{"name":"Mount Elizabeth Medical Centre  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Neri","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care Global Operational Artificial Intelligence and GenAI, Renal Research Institute  Vaiano Cremasco Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey L.","family":"Hymes","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care Deutschland GmbH Global Medical Office  Bad Homburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franklin W.","family":"Maddux","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care AG Global Medical Office  Waltham Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin E.","family":"Hippen","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care AG Global Medical Office  West Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5040-2310","authenticated-orcid":false,"given":"Milind","family":"Nikam","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care Global Medical Office  Dubai 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