{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:46:23Z","timestamp":1792035983735,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370902"],"award-info":[{"award-number":["82370902"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270935"],"award-info":[{"award-number":["81270935"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data on the efficacy and safety of sacubitril\/valsartan in hemodialysis patients with heart failure and preserved left ventricular ejection fraction (\u2265\u200950%, HFpEF) or mildly reduced left ventricular ejection fraction (41%\u201349%, HFmrEF) were analyzed, as well as cardiac functional parameters and safety after withdrawal of sacubitril\/valsartan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety\u2010eight maintenance hemodialysis patients with heart failure with preserved or mildly reduced ejection fraction were included in the present study. Patients were divided into sacubitril\/valsartan and control groups according to whether they had been, or were being, treated with sacubitril\/valsartan. Patients were further divided into continuation and discontinuation groups based on whether sacubitril\/valsartan was discontinued at the end of follow\u2010up. Laboratory examination results, echocardiographic parameters, and the occurrence of major adverse cardiac events were recorded and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 50 patients in the control group and 48 in the sacubitril\/valsartan group. The median follow\u2010up time was 14.5\u2009months. Compared with the control group, the serum B\u2010type natriuretic peptide levels and echocardiographic parameters in the sacubitril\/valsartan group significantly decreased from baseline at 6\u2010month follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In the sacubitril\/valsartan group, there were 28 patients in the continuation group and 20 in the discontinuation group. The reduction in left ventricular end\u2010diastolic diameter in the sacubitril\/valsartan group reversed in the discontinuation group (by 10%) after drug withdrawal, whereas it was stable in the continuation group (change 0.66%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030). Patients with lower left ventricular end\u2010diastolic diameters at the end follow\u2010up (\u2264\u200950\u2009mm) exhibited a lower incidence of major adverse cardiac events compared to those with higher diameters (&gt;50\u2009mm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sacubitril\/valsartan improved cardiac function in patients on hemodialysis with heart failure and preserved or mildly reduced left ventricular ejection fraction. Long\u2010term continuous use of sacubitril\/valsartan may reduce left ventricular end\u2010diastolic diameter and positively impact prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hdi.70076","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T07:02:09Z","timestamp":1777964529000},"page":"582-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in Cardiac Functional Parameters After Discontinuation of Sacubitril\/Valsartan in Hemodialysis Patients: Insights From Left Ventricular End\u2010Diastolic Diameter in Real\u2010World Observational Data"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3119-9398","authenticated-orcid":false,"given":"Ruibin","family":"He","sequence":"first","affiliation":[{"name":"Department of Nephrology, School of Medicine Baoshan Branch of Renji Hospital, Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Zhu","sequence":"additional","affiliation":[{"name":"Daning Community Health Service Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine Baoshan Branch of Renji Hospital, Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Physical Diagnosis, School of Medicine the Baoshan Branch of Renji Hospital, Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, School of Medicine Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University  Shanghai China"},{"name":"Shanghai National Clinical Research Center for Metabolic Diseases, School of Medicine Ruijin Hospital, Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine Renji Hospital Affiliated to Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangzi","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine Baoshan Branch of Renji Hospital, Shanghai Jiao Tong University  Shanghai China"},{"name":"Department of Nephrology, School of Medicine Renji Hospital Affiliated to Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.050686"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.132"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00605-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2021.06.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.039136"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.08.074"},{"issue":"9","key":"e_1_2_9_9_1","first-page":"897","article-title":"Heart Failure With Preserved Ejection Fraction","volume":"376","author":"Redfield M. M.","year":"2017","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-004-0460-0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41540-017-0013-4"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.02.004"},{"issue":"5","key":"e_1_2_9_13_1","first-page":"3439","article-title":"Effects and Safety of Sacubitril\/Valsartan (SV) on Heart Function and Blood Pressure in Maintenance Hemodialysis (MHD) Patients","volume":"14","author":"Wen Y.","year":"2022","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61966-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2015.1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12667"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13153"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-023-07481-w"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2333"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1531"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V451205"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199811000-00019"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.955780"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2022.11431"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1285929"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61227-6"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908655"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2023.2222841"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2005.08.003"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2018.01.019"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001193"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.06.004"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001878"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2022.07.001"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.70076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hdi.70076","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.70076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:04:48Z","timestamp":1792033488000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.70076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,5]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/hdi.70076"],"URL":"https:\/\/doi.org\/10.1111\/hdi.70076","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,5]]},"assertion":[{"value":"2025-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}