{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:46:23Z","timestamp":1792035983849,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Excess extracellular fluid volume (excess\n \n V\n ECF<\/jats:sub>\n <\/jats:italic>\n ) is associated with poor prognosis in dialysis patients. Although bioimpedance spectroscopy is widely used to assess excess\n \n V\n ECF<\/jats:sub>\n <\/jats:italic>\n \u2009, it requires specialized equipment. The aim of this study was to develop a novel method to estimate excess\n \n V\n ECF<\/jats:sub>\n <\/jats:italic>\n based on blood volume monitoring data.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We constructed a mathematical model to estimate excess\n \n V\n ECF<\/jats:sub>\n <\/jats:italic>\n using the relative blood volume at the end of dialysis. The estimated excess\n \n V\n ECF<\/jats:sub>\n <\/jats:italic>\n at the end of dialysis was compared with the bioimpedance spectroscopy\u2010derived excess\n \n V\n ECF<\/jats:sub>\n <\/jats:italic>\n measured immediately after the same dialysis session. The correlation and agreement between the two methods were evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A significant correlation was observed between blood volume\u2010based and bioimpedance spectroscopy\u2010derived excess\n \n V\n ECF<\/jats:sub>\n <\/jats:italic>\n (\n r<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090.7526,\n p<\/jats:italic>\n \u2009<\u20090.0001). Bland\u2013Altman analysis showed a fixed bias, indicating that blood volume\u2010based excess\n \n V\n ECF<\/jats:sub>\n <\/jats:italic>\n systematically overestimated bioimpedance spectroscopy\u2010derived excess\n \n V\n ECF<\/jats:sub>\n <\/jats:italic>\n at the end of dialysis, but no proportional bias was observed (mean difference\u2009=\u2009+0.86\u2009L\/m\n 2<\/jats:sup>\n ; 95% limits of agreement\u2009=\u2009\u22121.10 to +2.82\u2009L\/m\n 2<\/jats:sup>\n ;\n r<\/jats:italic>\n \u2009=\u20090.046).\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n \n Possible sources of estimation error in blood volume\u2010based excess\n \n V\n ECF<\/jats:sub>\n <\/jats:italic>\n include the assumption of isotonicity during dialysis and variability in the\n f<\/jats:italic>\n \u2010cell ratio.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The proposed blood volume\u2010based method for estimating excess\n \n V\n ECF<\/jats:sub>\n <\/jats:italic>\n demonstrated a significant correlation with bioimpedance spectroscopy\u2010derived values and may serve as a useful tool for volume assessment in dialysis patients. However, further validation is needed before it can be considered a substitute for bioimpedance spectroscopy as a standard method.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hdi.70079","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T03:40:28Z","timestamp":1778298028000},"page":"635-644","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Estimation of Excess Extracellular Fluid Volume Using Blood Volume Monitoring: A Comparison With Bioimpedance Spectroscopy. A Pilot Study"],"prefix":"10.1111","volume":"30","author":[{"given":"Shota","family":"Yoshizawa","sequence":"first","affiliation":[{"name":"Mihama Hospital Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Akazawa","sequence":"additional","affiliation":[{"name":"Satsukinomori Clinic Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Shinzato","sequence":"additional","affiliation":[{"name":"Aichi Clinic Toyohashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Shibata","sequence":"additional","affiliation":[{"name":"Toshin Clinic Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisato","family":"Nagao","sequence":"additional","affiliation":[{"name":"Sakai Clinic Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Mihama Hospital Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruki","family":"Saito","sequence":"additional","affiliation":[{"name":"Mihama Hospital Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Uchino","sequence":"additional","affiliation":[{"name":"Mihama Hospital Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoyuki","family":"Masai","sequence":"additional","affiliation":[{"name":"Mihama Hospital Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3493-9887","authenticated-orcid":false,"given":"Shigeru","family":"Nakai","sequence":"additional","affiliation":[{"name":"Daiko Medical Engineering Research Institute Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine Oita University Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0147-5273","authenticated-orcid":false,"given":"Takeshi","family":"Nakata","sequence":"additional","affiliation":[{"name":"Faculty of Welfare and Health Science Oita University Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"71","article-title":"Cardiovascular Disturbances in Hemodialysis Patients: The Importance of Volume Overload","volume":"8","author":"Dorhout Mees E. J.","year":"1995","journal-title":"Journal of Nephrology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg371"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.2.369"},{"key":"e_1_2_11_5_1","first-page":"25","article-title":"Influence of the Hydration State on Blood Pressure Values in a Group of Patients on Regular Maintenance Hemodialysis","volume":"15","author":"Dionisio P.","year":"1997","journal-title":"Blood Purification"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.1.80"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1916.00080130010002"},{"key":"e_1_2_11_8_1","first-page":"373","volume-title":"Guyton and Hall Textbook of Medical Physiology","author":"Hall J. E.","year":"2011"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-200205000-00021"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00880207"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb08411.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00467.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000521563"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.1986.tb02603.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.4.798"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn707"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn228"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.70079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hdi.70079","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.70079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:05:04Z","timestamp":1792033504000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.70079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/hdi.70079"],"URL":"https:\/\/doi.org\/10.1111\/hdi.70079","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]},"assertion":[{"value":"2026-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}