{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:45:24Z","timestamp":1792035924251,"version":"4.4.0"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intradialytic hypotension (IDH) is a frequent complication of hemodialysis (HD). Although nadir blood pressure\u2013based definitions are prognostically relevant, their use in daily practice is limited because accurate identification requires frequent blood pressure monitoring. Because blood pressure (BP) is routinely measured during HD, the magnitude of the systolic BP rise during blood return may provide a simple and practical marker for identifying IDH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study was conducted at a single HD center. Study 1 evaluated factors associated with the pressor response index in 53 HD patients across 159 sessions using analysis of covariance (ANCOVA). Study 2 examined the ability of the index to discriminate HD sessions with and without IDH as defined by McCausland et\u00a0al.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The pressor response index was significantly associated with maximum systolic BP drop and hypovolemic symptoms. The index clearly distinguished sessions with and without IDH. The effect size was large (Cohen's\n                      <jats:italic>d<\/jats:italic>\n                      \u2009=\u20091.41), and ROC analysis showed good discrimination (AUC 0.823). The optimal cut\u2010off value was 10.3% (sensitivity 0.84, specificity 0.65).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The pressor response index may represent a simple, objective, and practical marker for identifying IDH in routine clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hdi.70083","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T02:44:55Z","timestamp":1779072295000},"page":"600-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pressor Response Index During Blood Return as a Marker for Identifying Intradialytic Hypotension"],"prefix":"10.1111","volume":"30","author":[{"given":"Ai","family":"Akazawa","sequence":"first","affiliation":[{"name":"Satsukinomori Clinic  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Mihama Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Nephrology Minatonomori Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Shinzato","sequence":"additional","affiliation":[{"name":"Aichi Clinic  Toyohashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Shibata","sequence":"additional","affiliation":[{"name":"Toshin Clinic  Yokohama Japan"},{"name":"Department of Cardiology, Nephrology, and Hypertension Yokohama City University School of Medicine  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Horiba","sequence":"additional","affiliation":[{"name":"Satsukinomori Clinic  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kato","sequence":"additional","affiliation":[{"name":"Satsukinomori Clinic  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Satsukinomori Clinic  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Uchino","sequence":"additional","affiliation":[{"name":"Mihama Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoyuki","family":"Masai","sequence":"additional","affiliation":[{"name":"Mihama Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3493-9887","authenticated-orcid":false,"given":"Shigeru","family":"Nakai","sequence":"additional","affiliation":[{"name":"Daiko Medical Engineering Research Institute  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, Rheumatology and Nephrology, Faculty of Medicine Oita University  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0147-5273","authenticated-orcid":false,"given":"Takeshi","family":"Nakata","sequence":"additional","affiliation":[{"name":"Faculty of Welfare and Health Science Oita University  Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12627"},{"issue":"5","key":"e_1_2_14_3_1","first-page":"S1","article-title":"K\/DOQI Clinical Practice Guidelines on Hypertension and Antihypertensive Agents in Chronic Kidney Disease","volume":"43","author":"Kidney Disease Outcomes Quality Initiative (K\/DOQI)","year":"2004","journal-title":"American Journal of Kidney Diseases"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014020222"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2011.00560.x"},{"issue":"3","key":"e_1_2_14_6_1","first-page":"499","article-title":"Associations of Intradialytic Hypotension With Mortality, Hospitalization, and Blood Pressure Recovery","volume":"66","author":"McCausland F. R.","year":"2015","journal-title":"American Journal of Kidney Diseases"},{"key":"e_1_2_14_7_1","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000545113"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/tjem.tjem_182_23"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.70083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hdi.70083","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.70083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:59:35Z","timestamp":1792033175000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.70083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,17]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/hdi.70083"],"URL":"https:\/\/doi.org\/10.1111\/hdi.70083","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,17]]},"assertion":[{"value":"2025-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}