{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:54:31Z","timestamp":1791251671852,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Patients with end\u2010stage kidney disease face an extremely high risk of major adverse cardiovascular and cerebrovascular events. This study investigated the role of microRNA\u201026a in patients with end\u2010stage kidney disease who have been receiving long\u2010term hemodialysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Blood samples were collected from patients with chronic kidney disease stages I\u2013III and from those with end\u2010stage kidney disease. Basic clinical information was recorded for all participants. Serum expression of microRNA\u201026a was measured using real\u2010time quantitative polymerase chain reaction. Pearson correlation analysis was used to examine the relationships between microRNA\u201026a levels and clinical indicators, including serum albumin, estimated glomerular filtration rate, high\u2010sensitivity C\u2010reactive protein, serum creatinine, and blood urea nitrogen. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to evaluate the association of microRNA\u201026a with disease progression and the occurrence of major adverse cardiovascular and cerebrovascular events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum microRNA\u201026a levels were significantly lower in patients with end\u2010stage kidney disease compared with those with earlier\u2010stage chronic kidney disease. MicroRNA\u201026a expression showed a positive correlation with serum albumin and estimated glomerular filtration rate, and negative correlations with high\u2010sensitivity C\u2010reactive protein, serum creatinine, and blood urea nitrogen. ROC curve analysis demonstrated that serum microRNA\u201026a levels had good diagnostic value for identifying end\u2010stage kidney disease (area under the curve\u2009=\u20090.842). During follow\u2010up, the cumulative incidence of major adverse cardiovascular and cerebrovascular events was 14% at 12\u2009months, 22% at 24\u2009months, and 34% at 36\u2009months. MicroRNA\u201026a expression was significantly lower in patients who experienced these events. Both univariate and multivariate logistic regression analyses identified higher serum microRNA\u201026a levels as an independent protective factor against major adverse cardiovascular and cerebrovascular events in patients with end\u2010stage kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with end\u2010stage kidney disease receiving long\u2010term hemodialysis, microRNA\u201026a levels are associated with disease severity and the risk of major adverse cardiovascular and cerebrovascular events. Lower miR\u201026a expression may serve as a potential biomarker for disease monitoring and risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hdi.70086","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T03:16:16Z","timestamp":1781147776000},"page":"757-764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Low Serum\n                    <scp>microRNA<\/scp>\n                    \u201026a Levels and Major Adverse Cardiovascular or Cerebrovascular Events in Patients Undergoing Hemodialysis"],"prefix":"10.1111","volume":"30","author":[{"given":"Yuanfang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nephrology Gaoping District People's Hospital of Nanchong  Nanchong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wu","sequence":"additional","affiliation":[{"name":"Nephrology Department The Eighth Hospital of Wuhan (Wuhan Anorectal Hospital)  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuezhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Rheumatology and Immunology Department Haemodialysis Centre, Zhejiang Provincial People's Hospital Southeast Campus  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6057-1241","authenticated-orcid":false,"given":"Xianfang","family":"Wang","sequence":"additional","affiliation":[{"name":"Hospital Infection Control Office, Hubei Provincial Hospital of TCM  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfab020"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8100608"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00060"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2020.03440"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.849942"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003384"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.774436"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.702029"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103106"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.29579"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18099"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002978"},{"issue":"8","key":"e_1_2_8_14_1","first-page":"499","article-title":"MiR\u201026a Regulates Vascular Smooth Muscle Cell Calcification In\u00a0Vitro Through Targeting CTGF","volume":"118","author":"Wu W.","year":"2017","journal-title":"Bratislavsk\u00e9 Lek\u00e1rske Listy"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x20199106"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-11-201306040-00007"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu249"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0902710"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27134"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27108"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499646"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2022.2056486"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070112"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.09.005"},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","DOI":"10.1177\/10760296211072820","article-title":"Arterial\u2010Renal Syndrome in Patients With ESRD, a New Disease Paradigm","volume":"28","author":"Goldstein J.","year":"2022","journal-title":"Clinical and Applied Thrombosis\/Hemostasis: Official Journal of the International Academy of Clinical and Applied Thrombosis\/Hemostasis"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12731"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10251011"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.12.013"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000024616"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.05.002"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2020.03.018"}],"container-title":["Hemodialysis International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.70086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hdi.70086","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hdi.70086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:46:49Z","timestamp":1791251209000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hdi.70086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/hdi.70086"],"URL":"https:\/\/doi.org\/10.1111\/hdi.70086","archive":["Portico"],"relation":{},"ISSN":["1492-7535","1542-4758"],"issn-type":[{"value":"1492-7535","type":"print"},{"value":"1542-4758","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,10]]},"assertion":[{"value":"2025-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}