{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:54:47Z","timestamp":1791251687001,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Depression is prevalent in maintenance hemodialysis patients and is influenced by the interplay of physical and mental health. Rather than a direct antidepressant effect of dialyzer membrane type, improved clearance of middle and large uremic solutes may alleviate uremia\u2010related symptoms that indirectly influence mood and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective observational study compared changes in Beck Depression Inventory (BDI) scores over 6\u2009months between thrice\u2010weekly hemodialysis patients treated with Theranova\u2010400 or FX80 dialyzers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty participants were included (Theranova\u2010400\/FX80: 25\/25; median age 52.5 [27.7] years; 27 females; dialysis vintage 60 [86] months). The reduction in BDI scores did not differ significantly between the two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.203). In the within\u2010group analysis, a significant decline was observed in the FX80 arm (\u22124.72\u2009\u00b1\u20096.62,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) but not in the Theranova\u2010400 arm (\u22123.20\u2009\u00b1\u200910.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.199). However, in the subgroup of patients with baseline BDI scores &gt;\u200914, both dialyzer groups showed statistically significant decreases in BDI scores (FX80: 24.7\u2009\u00b1\u20097.3 to 16.5\u2009\u00b1\u20096.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016; Theranova\u2010400: 24.1\u2009\u00b1\u20098.4 to 14.8\u2009\u00b1\u200910,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this exploratory observational study, BDI scores decreased over 6\u2009months in both groups; however, between\u2010group change in BDI did not differ significantly. These findings do not support a dialyzer\u2010specific antidepressant effect of Theranova\u2010400 compared with FX80. Within\u2010group changes, particularly in the FX80 arm, should be interpreted cautiously considering possible repeated\u2010measurement effects, regression to the mean, and unmeasured confounding. Future studies should evaluate whether changes in uremic symptom burden mediate mood\u2010related scores.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hdi.70091","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T03:54:59Z","timestamp":1779422099000},"page":"765-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Medium Cut\u2010Off Versus High\u2010Flux Dialyzers and Changes in Beck Depression Inventory Scores in Maintenance Hemodialysis: An Exploratory Observational Study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5131-6983","authenticated-orcid":false,"given":"Fevzi Necati","family":"Avsar","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Health Sciences\u2014Mehmet Akif Inan Education and Research Hospital  Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8676-0136","authenticated-orcid":false,"given":"Osman","family":"Erinc","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Health Sciences\u2014Mehmet Akif Inan Education and Research Hospital  Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2015-4421","authenticated-orcid":false,"given":"Tuncay","family":"Sahutoglu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine University of Health Sciences\u2014Mehmet Akif Inan Education and Research Hospital  Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw249"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.08.031"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0111-1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy179"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12742"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744\u20109987.14031"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.77"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2017.01.009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000491014"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13620"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2016.09.005"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-015-0149-7"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-022-02957-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744\u20109987.14036"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfab223"},{"key":"e_1_2_10_17_1","article-title":"Effects of Medium Cut\u2010Off Versus High\u2010Flux Hemodialysis Membranes on Biomarkers: A Systematic Review and Meta\u2010Analysis","volume":"9","author":"Kandi M.","year":"2022","journal-title":"Canadian Journal of Kidney Health and Disease"},{"key":"e_1_2_10_18_1","first-page":"1","article-title":"Removal of Large Middle Molecules via Haemodialysis With Medium Cut\u2010Off Membranes at Lower Blood Flow Rates: An Observational Prospective Study","volume":"21","author":"Kim T. 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