{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:54:31Z","timestamp":1791251671758,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hemodialysis International"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Iron overload in chronic kidney disease contributes to oxidative injury. The role of iron chelators, standard in transfusion\u2010related overload, remains unclear in chronic kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of iron chelators in adults with chronic kidney disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis followed PRISMA 2020 guidelines. Databases were searched for randomized controlled trials and observational studies reporting on iron indices, hematological parameters, and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eleven studies (206 patients) were included. Iron chelation significantly reduced serum ferritin (weighted mean difference [WMD]: \u22121.48\u2009\u03bcg\/L; 95% CI: \u22122.09, \u22120.87), transferrin (WMD: \u221210.6\u2009mg\/dL; 95% CI: \u221215.6, \u22125.61), and serum iron (WMD: \u221224.2\u2009\u03bcg\/dL; 95% CI: \u221242.5, \u22125.9). Hemoglobin increased (WMD: 1.07\u2009g\/dL; 95% CI: 0.20, 1.94). Glucose levels decreased, but lipid parameters were unaffected. Evidence was limited by high heterogeneity and potential bias. Gastrointestinal adverse events were common; serious events were rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Iron chelation effectively reduces iron stores and may improve anemia in chronic kidney disease patients. However, the evidence is limited by small sample sizes and heterogeneity. High\u2010quality randomized controlled trials are needed to establish clinical utility and safety before routine use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hdi.70103","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T01:02:06Z","timestamp":1781830926000},"page":"745-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and Efficacy of Iron Chelators in Patients With Chronic Kidney Disease: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3621-0518","authenticated-orcid":false,"given":"Humam Emad","family":"Rajha","sequence":"first","affiliation":[{"name":"College of Medicine, QU Health, Qatar University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Shamoon","sequence":"additional","affiliation":[{"name":"Nursing and Midwifery Research Department Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameer","family":"Almeshagbeh","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular, and Developmental Biology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah","family":"Masry","sequence":"additional","affiliation":[{"name":"Nursing and Midwifery Research Department Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadel","family":"Alqatati","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baha H.","family":"Abuajameia","sequence":"additional","affiliation":[{"name":"College of Medicine, QU Health, Qatar University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-4119","authenticated-orcid":false,"given":"Abdulqadir J.","family":"Nashwan","sequence":"additional","affiliation":[{"name":"Nursing and Midwifery Research Department Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.07.012"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1526482"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496492"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2015.10.002"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.2255"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.13054"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2019.25.12.1377"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.865669"},{"issue":"4","key":"e_1_2_11_10_1","first-page":"411","article-title":"An Update on Iron Chelation Therapy","volume":"10","author":"Poggiali E.","year":"2012","journal-title":"Blood Transfusion = Trasfusione del Sangue"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/b906679a"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/516740"},{"key":"e_1_2_11_13_1","first-page":"239","article-title":"A Review on Iron Chelators in Treatment of Iron Overload Syndromes","volume":"10","author":"Mobarra N.","year":"2016","journal-title":"International Journal of Hematology\u2010Oncology and Stem Cell Research"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2016.02.001"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740330903535845"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.8914"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1989.311"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/jbm.S415604"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_11_21_1","volume-title":"The Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta\u2010Analyses","author":"Wells G. 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