{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:04:18Z","timestamp":1790143458542,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T00:00:00Z","timestamp":1357603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective.<\/jats:title>\n                    <jats:p>We intended to study the effect of check size on visual evoked potential habituation in interictal migraine, using the faster 3 per second reversal rate and an improved analytic procedure with block\u2010number blinding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background.<\/jats:title>\n                    <jats:p>Habituation in migraineurs has been extensively studied with visual evoked potentials. Despite discrepant results, possibly related to the use of different stimulus conditions, lack of habituation in the period between attacks is presently considered to be a neurophysiological hallmark of migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>\n                      Midoccipital monocular visual evoked potentials were recorded and analyzed in 27 interictal migraineurs and 34 healthy controls using a blinded study design. Small 8\u2032 checks and large 65\u2032 checks were applied in random order, both with 3 reversals per second. Six consecutive blocks of 100 responses were recorded for each check size.\n                      <jats:styled-content style=\"fixed-case\">N70\u2010P100<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">P100\u2010N145<\/jats:styled-content>\n                      peak\u2010to\u2010peak amplitudes were measured. Regression slopes across the 6 blocks, supplemented by last block\/first block ratio and repeated measures analysis of variance with amplitude as the dependent variable, were used to test for habituation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">N70\u2010P100<\/jats:styled-content>\n                      habituation to small and large checks was observed in controls (mean slope \u22120.30 and \u22120.11\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>\u03bc<\/jats:italic>\n                        V\n                      <\/jats:styled-content>\n                      \/block) and interictal migraineurs (\u22120.32 and \u22120.26\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>\u03bc<\/jats:italic>\n                        V\n                      <\/jats:styled-content>\n                      \/block).\n                      <jats:styled-content style=\"fixed-case\">P100\u2010N145<\/jats:styled-content>\n                      habituation to small checks in controls (mean slope \u22120.39\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>\u03bc<\/jats:italic>\n                        V\n                      <\/jats:styled-content>\n                      \/block) and to small and large checks in interictal migraineurs (\u22120.38 and \u22120.17\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>\u03bc<\/jats:italic>\n                        V\n                      <\/jats:styled-content>\n                      \/block) was also observed. None of the habituation measures were significantly different between healthy controls and migraineurs (F\u2009&lt;\u20091.6,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u2009.18). The check\u2010size effect was similar in the 2 groups (F\u2009&lt;\u20092.3,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u2009.14).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>\n                      Reversal rate and check\u2010size differences do not seem to explain the discrepant visual evoked potential habituation results in the migraine literature. Furthermore, no differences in first block amplitudes or\n                      <jats:styled-content style=\"fixed-case\">N70<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">P100<\/jats:styled-content>\n                      , and\n                      <jats:styled-content style=\"fixed-case\">N145<\/jats:styled-content>\n                      latencies between healthy controls and migraineurs were found. We recommend blinded evaluation designs in future habituation studies in migraine.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.12006","type":"journal-article","created":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T22:51:18Z","timestamp":1357685478000},"page":"1071-1086","source":"Crossref","is-referenced-by-count":68,"title":["Visual Evoked Potentials in Interictal Migraine: No Confirmation of Abnormal Habituation"],"prefix":"10.1111","volume":"53","author":[{"given":"Petter M.","family":"Omland","sequence":"first","affiliation":[{"name":"Department of Neuroscience Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian B.","family":"Nilsen","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Uglem","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f8ril","family":"Gravdahl","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Linde","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Department of Neurology Section for Clinical Neurophysiology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Norwegian University 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