{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T03:41:43Z","timestamp":1782013303490,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T00:00:00Z","timestamp":1356480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to examine chronic brain white matter hyperintensities in migraine and to gain data on the characteristics of the lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Migraine associates with a higher incidence of magnetic resonance imaging (\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      )\u2010visible white matter signal abnormalities. Several attack\u2010related pathomechanisms have been proposed in the lesion development, including the effect of repeated intracerebral hemodynamic changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Supratentorial white matter hyperintensities of 17 migraine patients were investigated interictally with quantitative\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      , including quantitative single voxel spectroscopy, diffusion, and perfusion\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      at 3.0\u2010\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      esla. The findings were compared with data measured in the contralateral, normal\u2010appearing white matter of migraineurs and in the white matter of 17 healthy subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significantly higher apparent diffusion coefficient values, prolonged\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      2 relaxation times, and decreased\n                      <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\n                      \u2010acetyl\u2010aspartate and creatine\/phosphocreatine concentrations were found in the white matter hyperintensities. The cerebral blood flow and blood volume values were mildly decreased inside the hyperintensities. Differences were not present between the migraine patients' normal\u2010appearing white matter and the white matter of healthy subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      measurements denote tissue damage with axonal loss, low glial cell density, and an enlarged extracellular space with an increased extracellular water fraction. These radiological features might be the consequences of microvascular ischemic changes during migraine attacks.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.12013","type":"journal-article","created":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T09:07:34Z","timestamp":1356512854000},"page":"752-763","source":"Crossref","is-referenced-by-count":39,"title":["Quantitative\n                    <scp>MRI<\/scp>\n                    Studies of Chronic Brain White Matter Hyperintensities in Migraine Patients"],"prefix":"10.1111","volume":"53","author":[{"given":"Mih\u00e1ly","family":"Aradi","sequence":"first","affiliation":[{"name":"Diagnostic Center of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Schwarcz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of P\u00e9cs  P\u00e9cs Hungary"},{"name":"Neuroscience MR Research Group Hungarian 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