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The aims of this paper are: (1) to review evidence regarding the magnitude of migraine; (2) to summarize information on the correlates and impact of migraine; and (3) to discuss the contributions, challenges, and future directions in the epidemiology of migraine. Evidence on the magnitude of migraine is divided into the following types of data: (1) prevalence rates of\n                      <jats:styled-content style=\"fixed-case\">ICHD<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      \u2010defined migraine and tension\u2010type headache from international population\u2010based studies of adults; (2) the magnitude of migraine in\n                      <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>\n                      .\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      . studies; (3)\n                      <jats:styled-content style=\"fixed-case\">ICHD<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      \u2010based international prevalence rates of\n                      <jats:styled-content style=\"fixed-case\">ICHD<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      \u2010defined migraine in children; and (4) incidence rates of migraine from prospective longitudinal studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A comprehensive review of the literature on the prevalence of migraine subtypes and tension\u2010type headache defined by\n                      <jats:styled-content style=\"fixed-case\">ICHD<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      criteria during the past decade was conducted and aggregate weighted rates across studies were derived.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Across the 19 studies of adults that employed the\n                      <jats:styled-content style=\"fixed-case\">ICHD<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      criteria, the aggregate weighted estimates of the 12\u2010month prevalence of definite migraine are 11.5%, and probable migraine of 7%, yielding a total of 18.5%. The cross\u2010study weighted aggregate rate of migraine with aura is 4.4%, chronic migraine is 0.5%, and of tension\u2010type headache is 13%. There has been even greater growth in international prevalence data on migraine in children, with a total of 21 studies of children that have employed the\n                      <jats:styled-content style=\"fixed-case\">ICDH<\/jats:styled-content>\n                      \u2010II criteria. The aggregate weighted rate of definite migraine in children is 10.1% and migraine with aura is 1.6%. The well\u2010established demographic correlates of migraine including the equal sex ratio in childhood, with increasing prevalence of migraine in females across adolescence to mid\u2010adulthood were confirmed in these studies. Despite increasing effort to increase awareness of migraine, approximately 50% of those with frequent and\/or severe migraine do not receive professional treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This review demonstrates that the descriptive epidemiology of migraine has reached its maturity. The prevalence rates and sociodemographic correlates have been stable across 50 years. These developments justify a shift in efforts to the application of the designs and methods of analytic epidemiology. Retrospective case\u2013control studies followed by prospective cohort studies that test specific associations are likely to enhance our understanding of the predictors of incidence and progression of migraine, subtypes of migraine with differential patterns of onset and course, and specific environmental exposures that may have either causal or provocative influences on migraine etiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.12038","type":"journal-article","created":{"date-parts":[[2013,2,23]],"date-time":"2013-02-23T05:48:50Z","timestamp":1361598530000},"page":"230-246","source":"Crossref","is-referenced-by-count":158,"title":["Contributions of Epidemiology to Our Understanding of Migraine"],"prefix":"10.1111","volume":"53","author":[{"given":"Kathleen R.","family":"Merikangas","sequence":"first","affiliation":[{"name":"Genetic Epidemiology Research Branch National Institute of Mental Health  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.38.6.613"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a036268"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01288.x"},{"issue":"1","key":"e_1_2_5_5_1","first-page":"3S","article-title":"The epidemiology of migraine","volume":"118","author":"Lipton RB","year":"2005","journal-title":"Am J Med"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.00671.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70062-0"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-008-0038-6"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2008.11.011"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.001460.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-009-0173-8"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-010-0146-2"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01941.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-010-0217-0"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2010.03793.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-010-0157-z"},{"key":"e_1_2_5_17_1","first-page":"1","article-title":"Epidemiology of headache","volume":"97","author":"Manzoni GC","year":"2011","journal-title":"Handb Clin Neurol"},{"issue":"7","key":"e_1_2_5_18_1","first-page":"1","article-title":"Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. 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