{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:12:26Z","timestamp":1762085546084,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T00:00:00Z","timestamp":1360713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2013,3]]},"abstract":"\n Background<\/jats:title>\n \n Migraine is associated with a significant economic burden in\n W<\/jats:styled-content>\n estern countries. However, there is limited information regarding the impact of the cost of migraine in\n A<\/jats:styled-content>\n sia.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To quantify and compare the direct medical costs of refractory migraine (\n RM<\/jats:styled-content>\n ) and other migraine, using health insurance claims data in\n T<\/jats:styled-content>\n aiwan.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A retrospective matched case\u2013control study was conducted utilizing data from the\n T<\/jats:styled-content>\n aiwan\n N<\/jats:styled-content>\n ational\n H<\/jats:styled-content>\n ealth\n I<\/jats:styled-content>\n nsurance\n R<\/jats:styled-content>\n esearch\n D<\/jats:styled-content>\n atabase.\n RM<\/jats:styled-content>\n cases were defined as patients with at least 1 neurological outpatient visit with a primary or secondary\n I<\/jats:styled-content>\n nternational\n C<\/jats:styled-content>\n lassification of\n D<\/jats:styled-content>\n iseases,\n N<\/jats:styled-content>\n inth\n R<\/jats:styled-content>\n evision,\n C<\/jats:styled-content>\n linical\n M<\/jats:styled-content>\n odification code of 346.11 (common migraine with intractable migraine, so stated), diagnosed by certified neurologists in medical centers during 2007\u20102008. The first control group was the non\u2010migraineurs matched with cases at a 4:1 ratio by age, gender, urbanization level of the residence, and income. The second control group was patients with other migraine types (346.00, 346.10, 346.20, 346.80, and 346.90) matched with cases at a 4:1 ratio by age, gender, and hospital setting. Medical utilization and costs within 365 days after the index visit date were assessed using a 2\u2010part model. The exchange rate for\n US<\/jats:styled-content>\n $1 was\n NT<\/jats:styled-content>\n $32.50.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patients with\n RM<\/jats:styled-content>\n had significantly higher total medical costs compared with non\u2010migraineurs (\n NT<\/jats:styled-content>\n $57,932 [\n US<\/jats:styled-content>\n $1783] vs\n NT<\/jats:styled-content>\n $26,817 [\n US<\/jats:styled-content>\n $825];\n P<\/jats:italic>\n \u2009<\u2009.001) or other migraineurs (\n NT<\/jats:styled-content>\n $54,678 [\n US<\/jats:styled-content>\n $1682] vs\n NT<\/jats:styled-content>\n $38,397 [\n US<\/jats:styled-content>\n $1181];\n P<\/jats:italic>\n \u2009<\u2009.001). The mean drug costs for those with\n RM<\/jats:styled-content>\n were also higher than for non\u2010migraineurs (\n NT<\/jats:styled-content>\n $19,752 [\n US<\/jats:styled-content>\n $608] vs\n NT<\/jats:styled-content>\n $8660 [\n US<\/jats:styled-content>\n $266];\n P<\/jats:italic>\n \u2009<\u2009.001) or those with other migraine (\n NT<\/jats:styled-content>\n $17,623 [\n US<\/jats:styled-content>\n $542] vs\n NT<\/jats:styled-content>\n $10,088 [\n US<\/jats:styled-content>\n $310];\n P<\/jats:italic>\n \u2009<\u2009.001). In addition, we reviewed the charts of all patients with an outpatient department diagnostic code of 346.11 (n\u2009=\u200998) at our hospital (\n T<\/jats:styled-content>\n aipei\n V<\/jats:styled-content>\n eterans\n G<\/jats:styled-content>\n eneral\n H<\/jats:styled-content>\n ospital, a medical center in\n T<\/jats:styled-content>\n aiwan) in 2007. Of these patients, 88 (90%) fulfilled the Silberstein\u2013\n L<\/jats:styled-content>\n ipton criteria for chronic migraine, ie, >15 headache days per month and presence of a history of migraine.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Refractory migraineurs in\n T<\/jats:styled-content>\n aiwan had significantly higher medical costs than either non\u2010migraineurs or those with other migraine diagnoses.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/head.12039","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T13:09:57Z","timestamp":1360760997000},"page":"526-539","source":"Crossref","is-referenced-by-count":9,"title":["A Retrospective Matched Case\u2013Control Study on Medical Costs of Refractory Migraine in\n T<\/scp>\n aiwan"],"prefix":"10.1111","volume":"53","author":[{"given":"Chao\u2010Hsiun","family":"Tang","sequence":"first","affiliation":[{"name":"School of Health Care Administration Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwong","family":"Ng","sequence":"additional","affiliation":[{"name":"Regional Health Outcomes Allergan Singapore Pte Ltd Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuu\u2010Jiun","family":"Wang","sequence":"additional","affiliation":[{"name":"Neurological Institute Taipei Veterans General Hospital Taipei"},{"name":"Faculty of Medicine and Institute of Brain Science National Yang\u2010Ming University School of Medicine Taipei 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