{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:44:39Z","timestamp":1791020679987,"version":"4.1.0"},"reference-count":85,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective.\u2014<\/jats:title>\n                    <jats:p>\n                      Chronic migraineurs (\n                      <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\n                      ) have painful intolerances to somatosensory, visual, olfactory, and auditory stimuli during and between migraine attacks. These intolerances are suggestive of atypical affective responses to potentially noxious stimuli. We hypothesized that atypical resting\u2010state functional connectivity (rs\u2010fc) of affective pain\u2010processing brain regions may associate with these intolerances. This study compared rs\u2010fc of affective pain\u2010processing regions in\n                      <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\n                      with controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.\u2014<\/jats:title>\n                    <jats:p>\n                      Twelve minutes of resting\u2010state blood oxygenation level\u2010dependent data were collected from 20 interictal adult\n                      <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\n                      and 20 controls. Rs\u2010fc between 5 affective regions (anterior cingulate cortex, right\/left anterior insula, and right\/left amygdala) with the rest of the brain was determined. Functional connections consistently differing between\n                      <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\n                      and controls were identified using summary analyses. Correlations between number of migraine years and the strengths of functional connections that consistently differed between\n                      <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\n                      and controls were calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.\u2014<\/jats:title>\n                    <jats:p>\n                      Functional connections with affective pain regions that differed in\n                      <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\n                      and controls included regions in anterior insula, amygdala, pulvinar, mediodorsal thalamus, middle temporal cortex, and periaqueductal gray. There were significant correlations between the number of years with\n                      <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\n                      and functional connectivity strength between the anterior insula with mediodorsal thalamus and anterior insula with periaqueductal gray.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.\u2014<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\n                      is associated with interictal atypical rs\u2010fc of affective pain regions with pain\u2010facilitating and pain\u2010inhibiting regions that participate in sensory\u2010discriminative, cognitive, and integrative domains of the pain experience. Atypical rs\u2010fc with affective pain regions may relate to aberrant affective pain processing and atypical affective responses to painful stimuli characteristic of\n                      <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.12081","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T20:54:43Z","timestamp":1361307283000},"page":"737-751","source":"Crossref","is-referenced-by-count":179,"title":["Atypical Resting\u2010State Functional Connectivity of Affective Pain Regions in Chronic Migraine"],"prefix":"10.1111","volume":"53","author":[{"given":"Todd J.","family":"Schwedt","sequence":"first","affiliation":[{"name":"Department of Neurology Washington University School of Medicine  St. Louis MO USA"},{"name":"Department of Anesthesiology Washington University School of Medicine  St. Louis MO 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