{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:17:30Z","timestamp":1790648250664,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T00:00:00Z","timestamp":1374537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2013,9]]},"abstract":"\n Background<\/jats:title>\n \n Despite the expanding therapeutic armamentarium, many people with episodic migraine (\n EM<\/jats:styled-content>\n ) have unmet acute treatment needs.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To determine the relative frequency of prespecified types of \u201cunmet treatment needs\u201d in persons with\n EM<\/jats:styled-content>\n in a\n US<\/jats:styled-content>\n population\u2010based sample.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Eligible participants completed the 2009\n A<\/jats:styled-content>\n merican\n M<\/jats:styled-content>\n igraine\n P<\/jats:styled-content>\n revalence and\n P<\/jats:styled-content>\n revention\n S<\/jats:styled-content>\n tudy survey and met International Classification of Headache Disorders\u20102nd edition (ICHD\u20102) criteria for migraine with an average headache day frequency of <15 days per month (\n EM<\/jats:styled-content>\n ). We identified 5 domains of unmet treatment needs: (1) dissatisfaction with current acute treatment using 3 summary items from the\n P<\/jats:styled-content>\n atient\n P<\/jats:styled-content>\n erception of\n M<\/jats:styled-content>\n igraine\n Q<\/jats:styled-content>\n uestionnaire\u2010revised edition (\n PPMQ\u2010R<\/jats:styled-content>\n ); (2) moderate or severe headache\u2010related disability defined by a\n M<\/jats:styled-content>\n igraine\n D<\/jats:styled-content>\n isability\n A<\/jats:styled-content>\n ssessment\n S<\/jats:styled-content>\n cale score of \u226511; (3) excessive use of opioids or barbiturates defined as use on \u22654\u2009days\/month or by meeting\n D<\/jats:styled-content>\n iagnostic and\n S<\/jats:styled-content>\n tatistical\n M<\/jats:styled-content>\n anual for\n M<\/jats:styled-content>\n ental\n D<\/jats:styled-content>\n isorders\u20104th edition criteria for dependence; (4) recurrent use of the emergency department or urgent care clinic for headache defined by \u22652 visits in the preceding year for headache; and (5) history of cardiovascular events indicating a possible contraindication to triptan use. For each respondent, we identified their unmet treatment needs in each category and classified them as having no unmet needs or 1 or more unmet needs.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 5591 respondents with\n EM<\/jats:styled-content>\n , 2274 (40.7%) had 1 or more unmet needs; 1467 (26.2%) had exactly 1 unmet need, and 807 (14.4%) had 2 or more unmet needs. Among those with at least 1 unmet need, 1069 (47.0%) had moderate or severe headache\u2010related disability, 851 (37.4%) were dissatisfied with their acute treatment regimen, 728 (32.0%) had excessive opioid or barbiturate use and\/or probable dependence, 595 (26.2%) had a history of cardiovascular events, and 129 (5.7%) reported \u22652 visits in the preceding year to the emergency department\/urgent care clinic for headache. Persons with more headache days, depression, or generalized anxiety were more likely to have unmet treatment needs.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In a population sample of individuals with EM, more than 40% have at least 1 unmet need in the area of acute treatment. The leading reasons for unmet needs, which include headache\u2010related disability and dissatisfaction with current acute treatment, suggest opportunities for improving outcomes for persons with\n EM<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/head.12154","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T11:44:46Z","timestamp":1374666286000},"page":"1300-1311","source":"Crossref","is-referenced-by-count":149,"title":["Examination of Unmet Treatment Needs Among Persons With Episodic Migraine: Results of the\n A<\/scp>\n merican\n M<\/scp>\n igraine\n P<\/scp>\n revalence and\n P<\/scp>\n revention (\n AMPP<\/scp>\n ) Study"],"prefix":"10.1111","volume":"53","author":[{"given":"Richard B.","family":"Lipton","sequence":"first","affiliation":[{"name":"Albert Einstein College of Medicine Bronx NY USA"},{"name":"Montefiore Medical Center Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn C.","family":"Buse","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine Bronx NY USA"},{"name":"Montefiore Medical Center Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Serrano","sequence":"additional","affiliation":[{"name":"Vedanta Research Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Starr","family":"Holland","sequence":"additional","affiliation":[{"name":"Armstrong Atlantic State University Savannah GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Reed","sequence":"additional","affiliation":[{"name":"Vedanta Research Chapel Hill NC 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