{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:20:43Z","timestamp":1767676843679,"version":"build-2065373602"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T00:00:00Z","timestamp":1372377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the influence of switching acute treatment on headache\u2010related disability in a population sample of individuals with migraine using acute triptan therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute treatments for migraine are often modified in clinical practice. The effect of changes in treatment from one triptan to another or from a triptan to another medication class has rarely been studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patterns of acute treatment for migraine were monitored from 1 year to the next in the\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      merican\n                      <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\n                      igraine\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      revalence and\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      revention (AMPP) Study for the following couplets (2005\u20102006, 2006\u20102007, 2007\u20102008, and 2008\u20102009). Changes in medication regimens were classified as follows: (1) switch within the triptan class; (2) switch to combination analgesics containing opioids or barbiturates; (3) switch to non\u2010steroidal anti\u2010inflammatory drug (\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      ) agents; (4) maintaining current therapy (consistent use, \u201ccontrol\u201d). We assessed change in migraine disability assessment scale score from the first to the second year of a couplet contrasting those with consistent use with those who changed acute treatment. Each individual contributed only 1 couplet to the analysis. Persons who added an acute treatment are considered in a separate manuscript. We modeled change in migraine disability assessment scale score as a function of change in medication regimen with consistent users as the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 81 individuals who switched to another triptan, with a referent of 619 who remained consistent, 31 cases who switched to an opioid or barbiturate with a referent of 666 who remained consistent, and 20 cases who switched to an\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      with a referent of 667 cases who remained consistent. In cell\u2010mean coded analyses of covariance (ANCOVA), switching from one triptan to another or switching from a triptan to an opioid\/barbiturate was never associated with significant improvements in headache\u2010related disability compared with consistent treatment. Switching from a triptan to an\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      was associated with significant increases in headache\u2010related disability among those with high\u2010frequency episodic\/chronic migraine (HFEM\/CM) compared with those with low\u2010frequency episodic migraine (LFEM) (interaction\u2009=\u200934.81, 95% confidence interval 10.61 to 59.00). The same was true comparing high\u2010frequency episodic\/chronic migraine with those with moderate\u2010frequency episodic migraine (interaction\u2009=\u200948.73, 95% confidence interval 2.63 to 94.83).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this observational study, switching triptan regimens does not appear to be associated with improvements in headache\u2010related disability and in some cases is associated with increased headache\u2010related disability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.12164","type":"journal-article","created":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T07:23:43Z","timestamp":1369380223000},"page":"1415-1429","source":"Crossref","is-referenced-by-count":24,"title":["Effects of Switching Acute Treatment on Disability in Migraine Patients Using Triptans"],"prefix":"10.1111","volume":"53","author":[{"given":"Daniel","family":"Serrano","sequence":"first","affiliation":[{"name":"Vedanta Research  Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn C.","family":"Buse","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine  Bronx NY USA"},{"name":"Montefiore Headache Center  Bronx NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashi H.","family":"Kori","sequence":"additional","affiliation":[{"name":"MAP Pharmaceuticals  Mountain View CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sypridon","family":"Papapetropoulos","sequence":"additional","affiliation":[{"name":"Miller School of Medicine University of Miami  Miami FL USA"},{"name":"Pfizer  Cambridge MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cedric M.","family":"Cunanan","sequence":"additional","affiliation":[{"name":"Allergan Inc.  Irvine CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aubrey N.","family":"Manack","sequence":"additional","affiliation":[{"name":"Allergan Inc.  Irvine CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Reed","sequence":"additional","affiliation":[{"name":"Vedanta Research  Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard B.","family":"Lipton","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine  Bronx NY USA"},{"name":"Montefiore Headache Center  Bronx NY 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