{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:58:06Z","timestamp":1762459086243,"version":"build-2065373602"},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T00:00:00Z","timestamp":1374537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2014,3]]},"abstract":"\n Objective<\/jats:title>\n \n To describe a case of pediatric central nervous system (\n CNS<\/jats:styled-content>\n ) venulitis.\n <\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n \n Primary angiitis of the\n CNS<\/jats:styled-content>\n is a rare but increasingly well\u2010recognized cause of morbidity in children. It primarily involves the arteries and arterioles of the\n CNS<\/jats:styled-content>\n , with only 1 published case of a pediatric patient found to have isolated\n CNS<\/jats:styled-content>\n venulitis on brain biopsy.\n <\/jats:p>\n <\/jats:sec>\n \n Case Report<\/jats:title>\n A 17\u2010year\u2010old female with a 4\u2010year history of migraines presented with increasingly frequent migraines and right\u2010sided hemiplegia. Infectious, hematologic, and rheumatologic work\u2010ups were negative. Brain magnetic resonance imaging showed multiple rim\u2010enhancing lesions consistent with calcifications affecting the deep left white matter. On brain biopsy, there was evidence of an inflammatory process involving small veins and venules. The patient displayed clinical improvement with a course of high\u2010dose steroids and 6 monthly cyclophosphamide infusions followed by maintenance therapy with mycophenolate mofetil.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n \n We describe a case of pediatric\n CNS<\/jats:styled-content>\n venulitis presenting with migraine.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/head.12188","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T11:44:51Z","timestamp":1374666291000},"page":"541-544","source":"Crossref","is-referenced-by-count":7,"title":["Central Nervous System Venulitis Presenting as Migraine"],"prefix":"10.1111","volume":"54","author":[{"given":"Serena L.","family":"Orr","sequence":"first","affiliation":[{"name":"Children's Hospital of Eastern Ontario ON Canada"},{"name":"University of Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlise P.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"University of Ottawa ON Canada"},{"name":"The Ottawa General Hospital ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Jurencak","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario ON Canada"},{"name":"University of Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Michaud","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario ON Canada"},{"name":"University of Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elka","family":"Miller","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario ON Canada"},{"name":"University of Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asif","family":"Doja","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario ON Canada"},{"name":"University of Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70081-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(05)70348-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32833c723d"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22075"},{"key":"e_1_2_6_6_1","first-page":"731","article-title":"Diagnosing central nervous system vasculitis in children","volume":"22","author":"Cellucci T","year":"2010","journal-title":"Pediatr Rev"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhead.12188","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.12188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:27:56Z","timestamp":1762079276000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.12188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,23]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/head.12188"],"URL":"https:\/\/doi.org\/10.1111\/head.12188","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"type":"print","value":"0017-8748"},{"type":"electronic","value":"1526-4610"}],"subject":[],"published":{"date-parts":[[2013,7,23]]}}}