{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:34:51Z","timestamp":1783168491892,"version":"3.54.6"},"reference-count":67,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,10]],"date-time":"2013-10-10T00:00:00Z","timestamp":1381363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    Medication overuse headache (\n                    <jats:styled-content style=\"fixed-case\">MOH<\/jats:styled-content>\n                    ) is a subset of chronic daily headache, occurring from overuse of 1 or more classes of migraine abortive medication. Acetaminophen, combination analgesics (caffeine combinations), opioids, barbiturates (butalbital), non\u2010steroidal anti\u2010inflammatory drugs, and triptans are the main classes of drugs implicated in the genesis of\n                    <jats:styled-content style=\"fixed-case\">MOH<\/jats:styled-content>\n                    . Migraine seems to be the most common diagnosis leading to\n                    <jats:styled-content style=\"fixed-case\">MOH<\/jats:styled-content>\n                    . The development of\n                    <jats:styled-content style=\"fixed-case\">MOH<\/jats:styled-content>\n                    is associated with both frequency of use of medication and behavioral predispositions.\n                    <jats:styled-content style=\"fixed-case\">MOH<\/jats:styled-content>\n                    is not a unitary concept. The distinction between simple (type 1) vs complex (type 2) forms is based on both the class of overused medication and behavioral factors, including psychopathology and psychological drug dependence.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">MOH<\/jats:styled-content>\n                    is a challenging disorder causing decline in the quality of life and causing physical symptoms, such as daily and incapacitating headaches, insomnia, and non\u2010restorative sleep, as well as psychological distress and reduced functioning.\n                    <jats:styled-content style=\"fixed-case\">MOH<\/jats:styled-content>\n                    is associated with biochemical, structural, and functional brain changes. Relapse after detoxification is a challenge, but can be addressed if the patient is followed over a prolonged period of time with a combination of prophylactic pharmacotherapy, use of abortive medication with minimal risk of\n                    <jats:styled-content style=\"fixed-case\">MOH<\/jats:styled-content>\n                    , withholding previously overused medication, and providing psychological (cognitive\u2010behavioral) therapy.\n                  <\/jats:p>","DOI":"10.1111\/head.12223","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T22:26:30Z","timestamp":1381530390000},"page":"211-217","source":"Crossref","is-referenced-by-count":50,"title":["Clinical Aspects of Medication Overuse Headaches"],"prefix":"10.1111","volume":"54","author":[{"given":"Arnaldo Neves","family":"Da Silva","sequence":"first","affiliation":[{"name":"MHNI 3120 Professional Drive  Ann Arbor MI 48104 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