{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:06:31Z","timestamp":1762430791170,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"a Griffith University Health Group Postgraduate scholarship"},{"name":"Australian International Science Linkages"},{"DOI":"10.13039\/501100001791","name":"Griffith University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001791","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2014,2]]},"abstract":"\n Background<\/jats:title>\n \n Migraine is a brain disorder affecting \u223c12% of the Caucasian population. Genes involved in neurological, vascular, and hormonal pathways have all been implicated in predisposing individuals to developing migraine. The migraineur presents with disabling head pain and varying symptoms of nausea, emesis, photophobia, phonophobia, and occasionally visual sensory disturbances. Biochemical and genetic studies have demonstrated dysfunction of neurotransmitters: serotonin, dopamine, and glutamate in migraine susceptibility. Glutamate mediates the transmission of excitatory signals in the mammalian central nervous system that affect normal brain function including cognition, memory and learning. The aim of this study was to investigate polymorphisms in the\n \n GRIA2<\/jats:styled-content>\n <\/jats:italic>\n and\n \n GRIA4<\/jats:styled-content>\n <\/jats:italic>\n genes, which encode subunits of the ionotropic\n AMPA<\/jats:styled-content>\n receptor for association in an\n A<\/jats:styled-content>\n ustralian\n C<\/jats:styled-content>\n aucasian population.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Genotypes for each polymorphism were determined using high resolution melt analysis and the\n RFLP<\/jats:styled-content>\n method.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Statistical analysis showed no association between migraine and the\n \n GRIA2<\/jats:styled-content>\n <\/jats:italic>\n and\n \n GRIA4<\/jats:styled-content>\n <\/jats:italic>\n polymorphisms investigated.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Although the results of this study showed no significant association between the tested\n \n GRIA<\/jats:styled-content>\n <\/jats:italic>\n gene variants and migraine in our\n A<\/jats:styled-content>\n ustralian\n C<\/jats:styled-content>\n aucasian population further investigation of other components of the glutamatergic system may help to elucidate if there is a relationship between glutamatergic dysfunction and migraine.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/head.12234","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T18:38:53Z","timestamp":1383071933000},"page":"303-312","source":"Crossref","is-referenced-by-count":9,"title":["Genetic Analysis of\n GRIA2<\/scp>\n and\n GRIA4<\/scp>\n Genes in Migraine"],"prefix":"10.1111","volume":"54","author":[{"given":"Claudia F.","family":"Gasparini","sequence":"first","affiliation":[{"name":"Genomics Research Centre Griffith Health Institute Griffith University Gold Coast QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi 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