{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:39:38Z","timestamp":1767339578865,"version":"build-2065373602"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T00:00:00Z","timestamp":1383091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2014,5]]},"abstract":"\n Background<\/jats:title>\n \n \n CACNA1A<\/jats:italic>\n <\/jats:styled-content>\n gene disorders present a variable familial phenotype of ataxia, migraine with aura, and\/or hemiplegic migraine. Prevalence data for these conditions are scarce.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n The aim of this study is to report a minimal prevalence estimate for familial hemiplegic migraine with cerebellar ataxia and spinocerebellar ataxia type 6 in\n P<\/jats:styled-content>\n ortugal.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This is a multisource population\u2010based prevalence study. Patients and families with spinocerebellar ataxia type 6 and familial hemiplegic migraine and cerebellar ataxia identified through the\n P<\/jats:styled-content>\n ortuguese survey of hereditary ataxias and spastic paraplegias were re\u2010evaluated. Prevalent patients were confirmed to be alive and affected at the 1st of\n J<\/jats:styled-content>\n anuary 2013.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One family with spinocerebellar ataxia type 6 and 2 families with other\n \n CACNA1A<\/jats:italic>\n <\/jats:styled-content>\n gene mutations were identified. From these families, 23 patients were alive and living in\n P<\/jats:styled-content>\n ortugal in the prevalence day, for an estimated national prevalence per 100,000 inhabitants of 0.21 for familial hemiplegic migraine with cerebellar ataxia and of 0.01 for spinocerebellar ataxia type 6.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The prevalence of familial hemiplegic migraine with cerebellar ataxia and spinocerebellar ataxia type 6 are both probably low in\n P<\/jats:styled-content>\n ortugal.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/head.12260","type":"journal-article","created":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T12:34:13Z","timestamp":1383136453000},"page":"911-915","source":"Crossref","is-referenced-by-count":6,"title":["The Prevalence of Familial Hemiplegic Migraine With Cerebellar Ataxia and Spinocerebellar Ataxia Type 6 in\n P<\/scp>\n ortugal"],"prefix":"10.1111","volume":"54","author":[{"given":"Jos\u00e9","family":"Barros","sequence":"first","affiliation":[{"name":"Hospital de Santo Ant\u00f3nio CHP \u2013 Centro Hospitalar do Porto Porto Portugal"},{"name":"ICBAS \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar Universidade do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Ruano","sequence":"additional","affiliation":[{"name":"Hospital de S\u00e3o Sebasti\u00e3o CHEDV \u2013 Centro Hospitalar de Entre Douro e Vouga Santa Maria da Feira Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana","family":"Domingos","sequence":"additional","affiliation":[{"name":"Hospital de Santo Ant\u00f3nio CHP \u2013 Centro Hospitalar do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assun\u00e7\u00e3o","family":"Tuna","sequence":"additional","affiliation":[{"name":"Hospital de Santo Ant\u00f3nio CHP \u2013 Centro Hospitalar do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana","family":"Dam\u00e1sio","sequence":"additional","affiliation":[{"name":"Hospital de Santo Ant\u00f3nio CHP \u2013 Centro Hospitalar do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Alonso","sequence":"additional","affiliation":[{"name":"IBMC \u2013 Instituto de Biologia Molecular e Celular Universidade do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Silveira","sequence":"additional","affiliation":[{"name":"IBMC \u2013 Instituto de Biologia Molecular e Celular Universidade do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Sequeiros","sequence":"additional","affiliation":[{"name":"IBMC \u2013 Instituto de Biologia Molecular e Celular Universidade do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Coutinho","sequence":"additional","affiliation":[{"name":"IBMC \u2013 Instituto de Biologia Molecular e Celular Universidade do Porto Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70048-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf132"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81373-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.591"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00371.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl334"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2660(08)01003-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.5.1243"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.9.1816"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp056"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080092"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000195686"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.1707"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhead.12260","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.12260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:59:50Z","timestamp":1762070390000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.12260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,30]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/head.12260"],"URL":"https:\/\/doi.org\/10.1111\/head.12260","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"type":"print","value":"0017-8748"},{"type":"electronic","value":"1526-4610"}],"subject":[],"published":{"date-parts":[[2013,10,30]]}}}