{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T17:57:53Z","timestamp":1778003873272,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T00:00:00Z","timestamp":1394668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Headaches occur commonly in all patients, including those who have brain tumors. Using the search terms \u201cheadache and brain tumors,\u201d \u201cintracranial neoplasms and headache,\u201d \u201cfacial pain and brain tumors,\u201d \u201cbrain neoplasms\/pathology,\u201d and \u201cheadache\/etiology,\u201d we reviewed the literature from the past 78 years on the proposed mechanisms of brain tumor headache, beginning with the work of\n                      <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\n                      enfield.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>Most of what we know about the mechanisms of brain tumor associated headache come from neurosurgical observations from intra\u2010operative dural and blood vessel stimulation as well as intra\u2010operative observations and anecdotal information about resolution of headache symptoms with various tumor\u2010directed therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is an increasing overlap between the primary and secondary headaches and they may actually share a similar biological mechanism. While there can be some criticism that the experimental work with dural and arterial stimulation produced head pain and not actual headache, when considered with the clinical observations about headache type, coupled with improvement after treatment of the primary tumor, we believe that traction on these structures, coupled with increased intracranial pressure, is clearly part of the genesis of brain tumor headache and may also involve peripheral sensitization with neurogenic inflammation as well as a component of central sensitization through trigeminovascular afferents on the meninges and cranial vessels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.12317","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T12:14:58Z","timestamp":1394712898000},"page":"772-775","source":"Crossref","is-referenced-by-count":32,"title":["Mechanism of Brain Tumor Headache"],"prefix":"10.1111","volume":"54","author":[{"given":"Lynne P.","family":"Taylor","sequence":"first","affiliation":[{"name":"Hematology\u2010Oncology Department (Neuro\u2010Oncology) Tufts Medical Center  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,13]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000372092.96124.E6"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-012-0443-8"},{"key":"e_1_2_4_4_1","first-page":"399","article-title":"A contribution to the mechanism of intracranial pain","volume":"15","author":"Penfield W","year":"1935","journal-title":"Assoc Res Nerv Ment Dis"},{"key":"e_1_2_4_5_1","first-page":"178","article-title":"Innervation of intracranial blood vessels and dural sinuses","volume":"18","author":"McNaughton F","year":"1938","journal-title":"Assoc Res Nerv Ment Dis"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1940.02280070051003"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1940.01210040002001"},{"key":"e_1_2_4_8_1","first-page":"445","volume-title":"Intracranial Tumors of Infancy and Childhood","author":"Bailey P","year":"1939"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1961.18.5.0605"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1971.34.5.0630"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902230105"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.4.555"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.9.1678"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1994.1404270.x"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1994.hed3407435.x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1999.1909787.x"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01368.x"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01970.x"},{"key":"e_1_2_4_19_1","first-page":"387","article-title":"Headache and brain tumours","volume":"30","author":"Kirby S","year":"2010","journal-title":"Cephalalgia"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-004-0274-8"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-007-0005-7"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2011.10.045"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhead.12317","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.12317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:49:15Z","timestamp":1762084155000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.12317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,13]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/head.12317"],"URL":"https:\/\/doi.org\/10.1111\/head.12317","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,13]]}}}