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Because of their unusual substrate, headaches in\n                      <jats:styled-content style=\"fixed-case\">HCTD<\/jats:styled-content>\n                      can derive from both common and uncommon circumstances.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                      hlers\u2013\n                      <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\n                      anlos hypermobile type can be recognized by multiple joint findings and its tendency to progress to a multisystem chronic pain syndrome.\n                      <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                      hlers\u2013\n                      <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\n                      anlos classic type also manifests joint laxity and similar pain complaints, but is differentiated by its skin laxity and fragility.\n                      <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                      hlers\u2013\n                      <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\n                      anlos vascular type presents the most severe risk due to blood vessel and hollow organ rupture.\n                      <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\n                      arfan syndrome demonstrates skeletal abnormalities, lens dislocations, and aortic root dilation that can result in dissection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In a headache patient, recognizing the presence of an\n                      <jats:styled-content style=\"fixed-case\">HCTD<\/jats:styled-content>\n                      improves the strategy for diagnosis and management. A brief review of findings related to joints, skin, and arteries may prompt further investigation into the\n                      <jats:styled-content style=\"fixed-case\">HCTD<\/jats:styled-content>\n                      s.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.12418","type":"journal-article","created":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T03:33:04Z","timestamp":1405481584000},"page":"1393-1402","source":"Crossref","is-referenced-by-count":29,"title":["Joint Hypermobility and Headache: Understanding the Glue That Binds the Two Together \u2013 Part 1"],"prefix":"10.1111","volume":"54","author":[{"given":"Derek","family":"Neilson","sequence":"first","affiliation":[{"name":"Division of Human Genetics Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent T.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Cincinnati  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,16]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"GeneReviews\u2122","author":"Dietz HC","year":"1993"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2012.01858.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410392606"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1999.1909791.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.191"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652409787581547"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35483"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12417"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.13.1916105"},{"key":"e_1_2_9_12_1","first-page":"265","article-title":"Collagen in tendon, ligament, and bone healing. 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