{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:43:36Z","timestamp":1792806216322,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,18]],"date-time":"2014-09-18T00:00:00Z","timestamp":1410998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"crossref","award":["R118-A11531"],"award-info":[{"award-number":["R118-A11531"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Trigeminus Foreningen","award":["-"],"award-info":[{"award-number":["-"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To prospectively describe the clinical characteristics of classical trigeminal neuralgia (\n                      <jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content>\n                      ) in a standardized manner.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content>\n                      is a rare disease and most clinicians only see a few patients. There is a lack of prospective systematic studies of the clinical characteristics of\n                      <jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content>\n                      . We hypothesized that contrary to current thinking, some\n                      <jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content>\n                      patients suffer from sensory abnormalities at neurological examination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Clinical characteristics such as demographics, pain characteristics, and comorbidities were systematically and prospectively collected from consecutive\n                      <jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content>\n                      patients in a tertiary referral center in a cross\u2010sectional study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 158 patients were included. Average age of onset was 52.9 years.\n                      <jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content>\n                      was more prevalent in women (95; 60%) than in men (63; 40%),\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u2009.011, and more often located on the right (89; 56%) than on the left side (64; 41%),\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u2009.043. It affected solely the second and\/or third trigeminal branch in 109 (69%) while the first branch alone was affected in only 7 (4%). Notably, 78 (49%) had concomitant persistent pain in addition to paroxysmal stabbing pain. Autonomic symptoms were present in 48 (31%). Patients who had not undergone surgery for\n                      <jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content>\n                      had sensory abnormalities in 35 (29%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This, the first study in a series of papers focusing on the clinical, radiological, and etiological aspects of\n                      <jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content>\n                      , revealed that the symptomatology of\n                      <jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content>\n                      includes a high percentage of concomitant persistent pain, autonomic symptoms, and sensory abnormalities. These findings offer new insights to the prevailing clinical impression of the clinical characteristics in\n                      <jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.12441","type":"journal-article","created":{"date-parts":[[2014,9,18]],"date-time":"2014-09-18T00:59:14Z","timestamp":1411001954000},"page":"1574-1582","source":"Crossref","is-referenced-by-count":311,"title":["Trigeminal Neuralgia \u2013 A Prospective Systematic Study of Clinical Characteristics in 158 Patients"],"prefix":"10.1111","volume":"54","author":[{"given":"Stine","family":"Maarbjerg","sequence":"first","affiliation":[{"name":"Danish Headache Center Department of Neurology Glostrup Hospital University of Copenhagen  Glostrup 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