{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:56:12Z","timestamp":1792000572987,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T00:00:00Z","timestamp":1413417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective\/Background<\/jats:title>\n                    <jats:p>\n                      The aim of this longitudinal study was to investigate changes of migraine\u2010related brain white matter hyperintensities 3 years after an initial study. Baseline quantitative magnetic resonance imaging (\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      ) studies of migraine patients with hemispheric white matter hyperintensities performed in 2009 demonstrated signs of tissue damage within the hyperintensities. The hyperintensities appeared most frequently in the deep white matter of the frontal lobe with a similar average hyperintensity size in all hemispheric lobes. Since in this patient group the repeated migraine attacks were the only known risk factors for the development of white matter hyperintensities, the remeasurements of migraineurs after a 3\u2010year long follow\u2010up may show changes in the status of these structural abnormalities as the effects of the repeated headaches.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The same patient group was reinvestigated in 2012 using the same\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      scanner and acquisition protocol.\n                      <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n                      measurements were performed on a 3.0\u2010\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      esla clinical\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      scanner. Beyond the routine\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      1\u2010,\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      2\u2010weighted, and fluid\u2010attenuated inversion recovery imaging, diffusion and perfusion\u2010weighted imaging, proton magnetic resonance spectroscopy, and\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      1 and\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      2 relaxation time measurements were also performed. Findings of the baseline and follow\u2010up studies were compared with each other.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The follow\u2010up proton magnetic resonance spectroscopy studies of white matter hyperintensities showed significantly decreased\n                      <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>\n                      \u2010acetyl\u2010aspartate (median values 8.133 vs 7.153\u2009mmol\/L,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.009) and creatine\/phosphocreatine (median values 4.970 vs 4.641\u2009mmol\/L,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.015) concentrations compared to the baseline, indicating a more severe axonal loss and glial hypocellularity with decreased intracellular energy production. The diffusion values, the\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      1 and\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      2 relaxation times, and the cerebral blood flow and volume measurements presented only mild changes between the studies. The number (median values 21 vs 25,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and volume (median values 0.896 vs 1.140\u2009mL,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001) of hyperintensities were significantly higher in the follow\u2010up study. No changes were found in the hemispheric and lobar distribution of hyperintensities. An increase in the hyperintensity size of preexisting lesions was much more common than a decrease (median values 14 vs 5,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.004). A higher number of newly developed hyperintensities were detected than disappeared ones (130 vs 22), and most of them were small (&lt;.034\u2009mL). Small white matter hyperintensities in patients with a low migraine attack frequency had a higher chance to disappear than large white matter hyperintensities or white matter hyperintensities in patients with a high attack frequency (coefficient: \u22120.517,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.034).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This longitudinal\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      study found clinically silent brain white matter hyperintensities to be predominantly progressive in nature. The absence of a control group precludes definitive conclusions about the nature of these changes or if their degree is beyond normal aging.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.12459","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T04:28:07Z","timestamp":1413433687000},"page":"55-70","source":"Crossref","is-referenced-by-count":55,"title":["Changes of Migraine\u2010Related White Matter Hyperintensities After 3 Years: A Longitudinal\n                    <scp>MRI<\/scp>\n                    Study"],"prefix":"10.1111","volume":"55","author":[{"given":"Szilvia","family":"Erd\u00e9lyi\u2010B\u00f3tor","sequence":"first","affiliation":[{"name":"Department of Neurology University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mih\u00e1ly","family":"Aradi","sequence":"additional","affiliation":[{"name":"Diagnostic Center of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Olayinka","family":"Kamson","sequence":"additional","affiliation":[{"name":"Department of Neurology University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Neurology University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Perlaki","sequence":"additional","affiliation":[{"name":"Department of Neurology University of P\u00e9cs  P\u00e9cs Hungary"},{"name":"Diagnostic Center of P\u00e9cs  P\u00e9cs Hungary"},{"name":"MTA\u2010PTE Clinical Neuroscience MR Research Group  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gergely","family":"Orsi","sequence":"additional","affiliation":[{"name":"Department of Neurology University of P\u00e9cs  P\u00e9cs Hungary"},{"name":"Diagnostic Center of P\u00e9cs  P\u00e9cs Hungary"},{"name":"MTA\u2010PTE Clinical Neuroscience MR Research Group  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szilvia Anett","family":"Nagy","sequence":"additional","affiliation":[{"name":"Diagnostic Center of P\u00e9cs  P\u00e9cs Hungary"},{"name":"Department of Radiography Faculty of Health Sciences University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Schwarcz","sequence":"additional","affiliation":[{"name":"MTA\u2010PTE Clinical Neuroscience MR Research Group  P\u00e9cs Hungary"},{"name":"Department of Neurosurgery University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"D\u00f3czi","sequence":"additional","affiliation":[{"name":"MTA\u2010PTE Clinical Neuroscience MR Research Group  P\u00e9cs Hungary"},{"name":"Department of Neurosurgery University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1muel","family":"Komoly","sequence":"additional","affiliation":[{"name":"Department of Neurology University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Deli","sequence":"additional","affiliation":[{"name":"Department of Neurology University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Trauninger","sequence":"additional","affiliation":[{"name":"Department of Neurology University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Pfund","sequence":"additional","affiliation":[{"name":"Department of Neurology University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,16]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","first-page":"1","article-title":"The International Classification of Headache Disorders, 2nd edn","volume":"24","author":"Headache Classification Committee of the International Headache Society","year":"2004","journal-title":"Cephalalgia"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.4.427"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh542"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000206446.26702.e9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01904.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c7357"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a6cb32"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1992.hed3206287.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1995.hed3505264.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2008.01133.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-011-0299-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.6.1736"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12013"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330109"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1179\/174313208X341003"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.600114"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000319691.50117.54"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2011.07.044"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.698"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000068408.82115.D2"},{"key":"e_1_2_8_22_1","unstructured":"3D Slicer.3D Slicer website2010.http:\/\/slicer.org\/accessed September 27 2010."},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1040"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002470050470"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1999.0511"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2008.02.033"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102409355660"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.14276"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2012.10.033"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01317.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01604.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2324"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.676346"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a8235b"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2011.00643.x"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhead.12459","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.12459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:17:56Z","timestamp":1762078676000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.12459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,16]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/head.12459"],"URL":"https:\/\/doi.org\/10.1111\/head.12459","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,16]]}}}