{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:14:04Z","timestamp":1771258444233,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T00:00:00Z","timestamp":1419811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2015,1]]},"abstract":"\n Objective<\/jats:title>\n \n To assess the relief of migraine pain, especially in the acute phase, by comparing active treatment, ie, kinetic oscillation stimulation (\n KOS<\/jats:styled-content>\n ) in the nasal cavity, with placebo.\n <\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n \n Exploratory trials testing the efficacy of\n KOS<\/jats:styled-content>\n on migraine patients indicated that this treatment could be a fast\u2010acting remedy for acute migraine pain.\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n Thirty\u2010six patients were randomized 1:1 using a placebo module to active or placebo treatment in this double\u2010blinded parallel design study. Treatment was administered with a minimally invasive inflatable tip oscillating catheter. Symptom scores (0\u201310 visual analog scale) were obtained before treatment, every 5 minutes during treatment, at 15 minutes, 2, and 24 hours post\u2010treatment, as well as daily (0\u20133 migraine pain scale) from 30 days pretreatment until\n D<\/jats:styled-content>\n ay 60 post. Thirty\u2010five patients were evaluated (active n\u2009=\u200918, placebo n\u2009=\u200917). The primary end\u2010point was the change in average pain score from before treatment to 15 minutes after treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patients who received active treatment reported reduced pain, eg, average visual analog scale pain scores fell from 5.5 before treatment to 1.2 15 minutes after, while the corresponding scores for recipients of placebo fell from 4.9 to 3.9. The changes in pain scores differed between the 2 treatments by 3.3 points (95% confidence interval: 2.3, 4.4),\n P<\/jats:italic>\n \u2009<\u2009.001. Already 5 minutes into the treatment, the difference (1.9 points) was significant (\n P<\/jats:italic>\n \u2009=\u2009.007). The difference was likewise significant at 2 hours post\u2010treatment (3.7 points,\n P<\/jats:italic>\n \u2009<\u2009.001). One patient experienced an adverse event (a vasovagal reaction with full spontaneous recovery) during placebo treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n KOS<\/jats:styled-content>\n is an effective and safe treatment for acute migraine pain.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/head.12485","type":"journal-article","created":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T09:34:00Z","timestamp":1419845640000},"page":"117-127","source":"Crossref","is-referenced-by-count":23,"title":["Kinetic Oscillation Stimulation as Treatment of Acute Migraine: A Randomized, Controlled Pilot Study"],"prefix":"10.1111","volume":"55","author":[{"given":"Jan\u2010Erik","family":"Juto","sequence":"first","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology Division of ENT Diseases Karolinska University Hospital Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf G.","family":"Hallin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Division of Clinical Neurophysiology Karolinska University Hospital Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra010917"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00404.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.01972.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411433042"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00895.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1999.3908543.x"},{"key":"e_1_2_9_8_1","first-page":"293","article-title":"The anatomical and clinical relations of the sphenopalatine (Meckel's) ganglion to the nose and its accessory sinuses","volume":"28","author":"Sluder G","year":"1909","journal-title":"NY Med J."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2013.861927"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-14-86"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411417901"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg158"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.1.193"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01814.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413512032"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.01966.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3057"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412473667"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhead.12485","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.12485","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/head.12485","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.12485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:17:59Z","timestamp":1762078679000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.12485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,29]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/head.12485"],"URL":"https:\/\/doi.org\/10.1111\/head.12485","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,29]]}}}