{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:05:52Z","timestamp":1769835952259,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T00:00:00Z","timestamp":1421625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"This study was supported by funding from the Nutrica Research Foundation project grant and the Department of Innovation, Industry, Science and Research- Funding agreement: International Science Linkages grant. R. Lea was supported partially by a Corbett Research Fellowship."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2015,2]]},"abstract":"\n Background<\/jats:title>\n \n Migraine is a highly disabling disease affecting a significant proportion of the\n A<\/jats:styled-content>\n ustralian population. The methylenetetrahydrofolate reductase (\n MTHFR<\/jats:styled-content>\n )\n C<\/jats:styled-content>\n 677\n T<\/jats:styled-content>\n variant has been associated with increased levels of homocysteine and risk of migraine with aura (\n MA<\/jats:styled-content>\n ). Folic acid (\n FA<\/jats:styled-content>\n ), vitamin\n B<\/jats:styled-content>\n 6<\/jats:sub>\n , and\n B<\/jats:styled-content>\n 12<\/jats:sub>\n supplementation has been previously shown to reduce increased levels of homocysteine and decrease migraine symptoms. However, the influence of dietary folate intake on migraine has been unclear. The aim of the current study was to analyze the association of dietary folate intake in the form of dietary folate equivalent,\n FA<\/jats:styled-content>\n , and total food folate (\n TFF<\/jats:styled-content>\n ) on migraine frequency, severity, and disability.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A cohort of 141 adult females of\n C<\/jats:styled-content>\n aucasian descent with\n MA<\/jats:styled-content>\n was genotyped for the\n MTHFR C<\/jats:styled-content>\n 677\n T<\/jats:styled-content>\n variant using restriction enzyme digestion. Dietary folate information was collected from all participants and analyzed using the \u201c\n F<\/jats:styled-content>\n ood\n W<\/jats:styled-content>\n orks\u201d 2009 package. Folate consumption was compared with migraine frequency, severity, and disability using linear regression.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A significant inverse relation was observed between dietary folate equivalent (\n R<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090.201, B\u2009=\u2009\u22120.002,\n P<\/jats:italic>\n \u2009=\u2009.045, 95% confidence interval [CI] [\u22120.004, \u22120.001]) and\n FA<\/jats:styled-content>\n (\n R<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090.255, B\u2009=\u2009\u22120.005,\n P<\/jats:italic>\n \u2009=\u2009.036, 95% CI [\u22120.009, \u22120.002]) consumption and migraine frequency. It was also observed that in individuals with the\n CC<\/jats:styled-content>\n genotype for the\n MTHFR C<\/jats:styled-content>\n 677\n T<\/jats:styled-content>\n variant, migraine frequency was significantly linked to\n FA<\/jats:styled-content>\n consumption (\n R<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u20090.106, B\u2009=\u2009\u22120.004,\n P<\/jats:italic>\n \u2009=\u2009.029, 95% CI [\u22120.007, \u22120.004]).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The results from this study indicate that folate intake in the form of\n FA<\/jats:styled-content>\n may influence migraine frequency in female\n MA<\/jats:styled-content>\n sufferers.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/head.12490","type":"journal-article","created":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T04:57:30Z","timestamp":1421643450000},"page":"301-309","source":"Crossref","is-referenced-by-count":34,"title":["Effects of Dietary Folate Intake on Migraine Disability and Frequency"],"prefix":"10.1111","volume":"55","author":[{"given":"Saras","family":"Menon","sequence":"first","affiliation":[{"name":"Genomics Research Centre Institute for Health and Biomedical Innovation Queensland University of Technology Kelvin Grove QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney A.","family":"Lea","sequence":"additional","affiliation":[{"name":"Genomics Research Centre Institute for Health and Biomedical Innovation Queensland University of Technology Kelvin Grove QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Ingle","sequence":"additional","affiliation":[{"name":"Griffith Health Institute Griffith University Gold Coast QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Genomics Research Centre Institute for Health and Biomedical Innovation Queensland University of Technology Kelvin Grove QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"Wee","sequence":"additional","affiliation":[{"name":"Griffith Health Institute Griffith University Gold Coast QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa M.","family":"Haupt","sequence":"additional","affiliation":[{"name":"Genomics Research Centre Institute for Health and Biomedical Innovation Queensland University of Technology Kelvin Grove QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Palmer","sequence":"additional","affiliation":[{"name":"Griffith Health Institute Griffith University Gold Coast QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6774-5475","authenticated-orcid":false,"given":"Lyn R.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Genomics Research Centre Institute for Health 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