{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T21:54:59Z","timestamp":1772488499767,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T00:00:00Z","timestamp":1426723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K08NS066087"],"award-info":[{"award-number":["K08NS066087"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Photophobia is a debilitating feature of many headache disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Overview<\/jats:title>\n                    <jats:p>Clinical and preclinical research has identified several potential pathways involved in enhanced light sensitivity. Some of these structures include trigeminal afferents in the eye, second\u2010order neurons in the trigeminal nucleus caudalis, third\u2010order neurons in the posterior thalamus, modulatory neurons in the hypothalamus, and fourth\u2010order neurons in the visual and somatosensory cortices. It is unclear to what degree each site plays a role in establishing the different temporal patterns of photophobia across different disorders. Peptides such as calcitonin gene\u2010related peptide and pituitary adenylate cyclase\u2010activating polypeptide may play a role in photophobia at multiple levels of the visual and trigeminal pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While our understanding of photophobia has greatly improved in the last decade, there are still unanswered questions. These answers will help us develop new therapies to provide relief to patients with primary headache disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.12532","type":"journal-article","created":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T06:52:26Z","timestamp":1426747946000},"page":"600-604","source":"Crossref","is-referenced-by-count":46,"title":["Photophobia in Primary Headaches"],"prefix":"10.1111","volume":"55","author":[{"given":"Heather L.","family":"Rossi","sequence":"first","affiliation":[{"name":"Department of Neurology Perelman School of Medicine University of Pennsylvania &amp; Children's Hospital of Pennsylvania  Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Recober","sequence":"additional","affiliation":[{"name":"Department of Neurology Perelman School of Medicine University of Pennsylvania &amp; Children's Hospital of Pennsylvania  Philadelphia PA 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