{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:56:56Z","timestamp":1792000616703,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"S4","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Although triptans are widely used in the acute management of migraine, there is uncertainty around the comparative efficacy of triptans among each other and vs non\u2010triptan migraine treatments. We conducted systematic reviews and network meta\u2010analyses to compare the relative efficacy of triptans (alone or in combination with other drugs) for acute treatment of migraines compared with other triptan agents, non\u2010steroidal anti\u2010inflammatory drugs (\n                      <jats:styled-content style=\"fixed-case\">NSAIDs<\/jats:styled-content>\n                      ), acetylsalicylic acid (\n                      <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>\n                      ), acetaminophen, ergots, opioids, or anti\u2010emetics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      ochrane Library,\n                      <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>\n                      , and\n                      <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>\n                      were searched for randomized controlled trials that compared triptans (alone or in combination with other drugs) with placebo\u2010controlled or active migraine treatments. Study selection, data extraction, and quality assessment were completed independently by multiple reviewers. Outcome data were combined and analyzed using a\n                      <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                      ayesian network meta\u2010analysis. For each outcome, odds ratios, relative risks, and absolute probability of response were calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 133 randomized controlled trials met the inclusion criteria. Standard dose triptans relieved headaches within 2 hours in 42 to 76% of patients, and 2\u2010hour sustained freedom from pain was achieved for 18 to 50% of patients. Standard dose triptans provided sustained headache relief at 24 hours in 29 to 50% of patients, and sustained freedom from pain in 18 to 33% of patients. Use of rescue medications ranged from 20 to 34%. For 2\u2010hour headache relief, standard dose triptan achieved better outcomes (42 to 76% response) than ergots (38%); equal or better outcomes than\n                      <jats:styled-content style=\"fixed-case\">NSAIDs<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>\n                      , and acetaminophen (46 to 52%); and equal or slightly worse outcomes than combination therapy (62 to 80%). Among individual triptans, sumatriptan subcutaneous injection, rizatriptan\n                      <jats:styled-content style=\"fixed-case\">ODT<\/jats:styled-content>\n                      , zolmitriptan\n                      <jats:styled-content style=\"fixed-case\">ODT<\/jats:styled-content>\n                      , and eletriptan tablets were associated with the most favorable outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation\/Conclusions<\/jats:title>\n                    <jats:p>\n                      Triptans are effective for migraine relief. Standard dose triptans are associated with better outcomes than ergots, and most triptans are associated with equal or better outcomes compared with\n                      <jats:styled-content style=\"fixed-case\">NSAIDs<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>\n                      , and acetaminophen. Use of triptans in combination with\n                      <jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>\n                      or acetaminophen, or using alternative modes of administration such as injectables, may be associated with slightly better outcomes than standard dose triptan tablets.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.12601","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T16:57:06Z","timestamp":1436893026000},"page":"221-235","source":"Crossref","is-referenced-by-count":281,"title":["Triptans in the Acute Treatment of Migraine: A Systematic Review and Network Meta\u2010Analysis"],"prefix":"10.1111","volume":"55","author":[{"given":"Chris","family":"Cameron","sequence":"first","affiliation":[{"name":"School of Epidemiology Public Health and Preventive Medicine University of Ottawa  Ottawa Canada"},{"name":"University of Ottawa Heart Institute  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Kelly","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Ching","family":"Hsieh","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Murphy","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Kotb","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Peterson","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doug","family":"Coyle","sequence":"additional","affiliation":[{"name":"School of Epidemiology Public Health and Preventive Medicine University of Ottawa  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Becky","family":"Skidmore","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Gomes","sequence":"additional","affiliation":[{"name":"Keenan Research Centre of the Li Ka Shing Knowledge Institute St. Michael's Hospital  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy","family":"Clifford","sequence":"additional","affiliation":[{"name":"School of Epidemiology Public Health and Preventive Medicine University of Ottawa  Ottawa Canada"},{"name":"CADTH  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Wells","sequence":"additional","affiliation":[{"name":"School of Epidemiology Public Health and Preventive Medicine University of Ottawa  Ottawa Canada"},{"name":"University of Ottawa Heart Institute  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health OrganizationFactsheet No. 277: Headache Disorders(Available at:http:\/\/www.who.int\/mediacentre\/factsheets\/fs277\/en\/). October2012(Accessed July 17 2014)."},{"key":"e_1_2_7_3_1","unstructured":"Using the Triptans to Treat: Migraine Headaches. Comparing Effectiveness Safety and Price: Consumer Reports Best Buy Drugs. March2013."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100118943"},{"key":"e_1_2_7_5_1","unstructured":"NICE.Headaches: Diagnosis and Management of Headaches in Young People and Adults (Clinical guideline 150: Methods Evidence and Recommendations): National Institute for Health and Clinical Excellence 2012. September2012."},{"key":"e_1_2_7_6_1","unstructured":"Sumamo SchellenbergE DrydenDM PasichnykD et\u2009al.Acute Migraine Treatment in Emergency Settings [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US);2012Nov. (Comparative Effectiveness Reviews No. 84.) Available at:http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK115368\/"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462312000517"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2001.00169.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06711-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/11537990-000000000-00000"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413508661"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X12458724"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys041"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3594"},{"key":"e_1_2_7_18_1","unstructured":"DiasS SuttonA WeltonN et\u2009al.NICE DSU Technical Support Document 2: Generalised Linear Modelling Framework for Pairwise and Network Meta\u2010Analysis of Randomised Controlled Trials. May2011[cited 2012 June 13]: Available at:http:\/\/www.nicedsu.org.uk\/TSD6%20Software.final.08.05.12.pdf."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008929526011"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1258\/jhsrp.2008.008020"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X12455847"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"issue":"7","key":"e_1_2_7_23_1","first-page":"1","article-title":"Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain","volume":"8","author":"Headache Classification Committee of the International Headache Society","year":"1988","journal-title":"Cephalalgia"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2008.01121.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.031286"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2006.00739.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2001.00218.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2007.01458.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2004.00295.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01313.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181a98e4d"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(03)00659-8"},{"key":"e_1_2_7_33_1","unstructured":"CoyleD LeeK SabarreK.Triptans for Migraine Therapy: A Pharmacoeconomic Analysis.2014. [Internet] Ontario Drug Policy Research Network. Available at:http:\/\/odprn.ca\/wp\u2010content\/uploads\/2014\/08\/Triptan\u2010PharmacoEcon\u2010Report\u2010CENSORED\u2010for\u2010review.pdf"},{"key":"e_1_2_7_34_1","unstructured":"National Institute for Health and Clinical Excellence.Diagnosis and management of headaches in young people and adults. Clinical Guideline 150. September2012. [Internet]. National Clinical Guideline Centre at The Royal College of Physicians London. Available at:http:\/\/www.ncbi.nlm.nih.gov\/pubmedhealth\/PMH0078140\/pdf\/TOC.pdf"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhead.12601","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.12601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T11:58:07Z","timestamp":1762084687000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.12601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":33,"journal-issue":{"issue":"S4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/head.12601"],"URL":"https:\/\/doi.org\/10.1111\/head.12601","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}