{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T20:32:20Z","timestamp":1764102740726,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea Health 21 R&D Project","award":["HI14C2348","A092058"],"award-info":[{"award-number":["HI14C2348","A092058"]}]},{"name":"Korean Society of Ginseng and National Research Foundation of Korea","award":["NRF2014R1A2A1A11051520"],"award-info":[{"award-number":["NRF2014R1A2A1A11051520"]}]},{"name":"Seoul National University Hospital Research Fund","award":["0420130280"],"award-info":[{"award-number":["0420130280"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2015,9]]},"abstract":"\n Objective\/Background<\/jats:title>\n \n Seasonal variation of migraine attack frequency has been described as a phenomenon. We aimed to compare functional disability and the occurrence of cranial autonomic symptoms (\n CASs<\/jats:styled-content>\n ) in patients who reported a seasonal variation in their migraine attack frequency with those who did not.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We conducted a questionnaire\u2010based observational study on patients with migraine without aura who visited our institution from\n J<\/jats:styled-content>\n anuary 2005 to\n D<\/jats:styled-content>\n ecember 2013. Patient demographics, headache characteristics, and accompanying symptoms were recorded, and functional disability was evaluated by\n M<\/jats:styled-content>\n igraine\n D<\/jats:styled-content>\n isability\n A<\/jats:styled-content>\n ssessment (\n MIDAS<\/jats:styled-content>\n )\n Q<\/jats:styled-content>\n uestionnaire.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 4423 patients screened, 769 were eligible for analysis, and 104 (13.5%) of them reported seasonal variation. Several\n CAS<\/jats:styled-content>\n features such as conjunctival injection (25.0% vs 14.0%), lacrimation (20.2% vs 10.8%), eyelid edema (20.2% vs 10.2%), forehead and facial sweating (22.1% vs 11.4%), and ptosis (23.1% vs 11.4%) were more prominent in this subset of patients. They showed higher\n MIDAS<\/jats:styled-content>\n scores (15.4\u2009\u00b1\u200923.5) than the other migraineurs (10.4\u2009\u00b1\u200916.9), with a 1.77\u2010fold increased risk (95% confidence interval 1.06\u20102.96) of severe functional disability (\n MIDAS<\/jats:styled-content>\n score \u226521) after adjustment for age group, sex, headache frequency, intensity, and duration. The higher the number of\n CASs<\/jats:styled-content>\n , the greater also was the proportion of patients with severe functional disability.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Patients who reported seasonal variation in migraine also reported more\n CASs<\/jats:styled-content>\n and had more severe functional disability. The profound functional disability in the migraineurs reporting seasonal variation or\n CAS<\/jats:styled-content>\n also provides direction for proactive clinical management in these patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/head.12613","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T08:12:59Z","timestamp":1437466379000},"page":"1112-1123","source":"Crossref","is-referenced-by-count":16,"title":["Seasonal Variation, Cranial Autonomic Symptoms, and Functional Disability in Migraine: A Questionnaire\u2010Based Study in Tertiary Care"],"prefix":"10.1111","volume":"55","author":[{"given":"Yong\u2010Won","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Neurology Seoul National University Hospital Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun\u2010Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Hospital 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