{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:48:02Z","timestamp":1778320082180,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T00:00:00Z","timestamp":1458172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Trigeminal neuralgia (TN) is one of the most agonizing facial pain disorders that humans endure. Studies on onabotulinum toxin A (BTX\u2010A) treatment for TN are limited, but promising with respect to TN of no identifiable cause. We aimed to investigate the efficiency and safety of BTX\u2010A treatment in a 60\u2010year\u2010old male with diabetes mellitus who in March 2013 presented with TN caused by an exostosis in Meckel's cave.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The patient was medically treatment refractory due to insufficient pain relief and adverse events of hyperglycemia, and surgery was declined due to complex anatomy. As a last resort, BTX\u2010A was injected into the pain trigger zones of the trigeminal nerve (V5).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Complete analgesia was reported 2 weeks after BTX\u2010A injection. Pain medications were discontinued and laboratory values returned to acceptable levels. Regular BTX\u2010A treatment during the next 28 months showed sustained analgesic effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BTX\u2010A has an excellent safety profile and may be efficient for patients with symptomatic TN not suited for conventional therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.12791","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T22:20:09Z","timestamp":1458339609000},"page":"1035-1039","source":"Crossref","is-referenced-by-count":15,"title":["Botulinum Toxin as Monotherapy in Symptomatic Trigeminal Neuralgia"],"prefix":"10.1111","volume":"56","author":[{"given":"Hanne Marie B\u00f8e","family":"Lunde","sequence":"first","affiliation":[{"name":"Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital Bergen Norway"},{"name":"Aleris Hospital and Medical Center Bergen Norway"},{"name":"Department of Clinical Medicine KG Jebsen MS Research Centre, University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d8ivind","family":"Torkildsen","sequence":"additional","affiliation":[{"name":"Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital Bergen Norway"},{"name":"Department of Clinical Medicine KG Jebsen MS Research Centre, University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"B\u00f8","sequence":"additional","affiliation":[{"name":"Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Kj\u00f8rsvik","family":"Bertelsen","sequence":"additional","affiliation":[{"name":"Aleris Hospital and Medical Center Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411424619"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24286"},{"key":"e_1_2_7_4_1","first-page":"831094","article-title":"Role of botulinum toxin type\u2010A (BTX\u2010A) in the management of trigeminal neuralgia","volume":"2013","author":"Verma G.","year":"2013","journal-title":"Pain Res Treat."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6410-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.3.418"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-15-65"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412441721"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-14-92"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e31829cb60e"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-15-43"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02185.x"},{"key":"e_1_2_7_13_1","first-page":"CD007312","article-title":"Neurosurgical interventions for the treatment of classical trigeminal neuralgia","volume":"7","author":"Zakrzewska JM","year":"2011","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211100916"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.04.043"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01678.x"}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhead.12791","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.12791","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T08:20:15Z","timestamp":1762071615000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.12791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,17]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/head.12791"],"URL":"https:\/\/doi.org\/10.1111\/head.12791","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,17]]}}}