{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:12Z","timestamp":1787014272494,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T00:00:00Z","timestamp":1473984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine total pituitary adenylate cyclase activating polypeptide (PACAP) in peripheral blood as a potential marker of the activation of the parasympathetic arm of the trigemino\u2010vascular system in chronic migraine (CM) in a case\u2010control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Women older than 17 and diagnosed as CM were recruited. Healthy women with no headache history and women with episodic migraine (EM) served as control groups. Total PACAP and vasoactive intestinal peptide (VIP) levels were determined in blood samples obtained from the right antecubital vein by ELISA outside a migraine attack and having taken no symptomatic medication the day before.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We assessed serum samples from 86 women with CM, 32 healthy women, and 35 women with EM. There were no differences in PACAP levels in CM patients (109.8\u2009\u00b1\u200943.8, 97.4 [32.5\u2013253.1] pg\/mL), controls (108.7\u2009\u00b1\u200943.0, 98.7 [50.7\u2013197.3] pg\/mL), or EM patients (98.8\u2009\u00b1\u200934.3, 94.2 [52.0\u2013190.7] pg\/mL). VIP levels were significantly increased (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.027) in CM as compared to control healthy women (136.0\u2009\u00b1\u2009111.5 pg\/mL; 103.1 [20.5\u2013534.0] pg\/mL vs 88.6\u2009\u00b1\u200961.0 pg\/mL; 66.0 [21.1\u2013256.1]) and EM patients (103.0\u2009\u00b1\u200956.7 pg\/mL; 103.5 [15.2\u2013263.0] pg\/mL). In the range of this study variables such as age, CM duration, the presence of aura, analgesic overuse, depression, fibromyalgia, vascular risk factors, history of triptan consumption or kind of preventative treatment did not significantly influence PACAP or VIP levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In contrast to VIP, interictal PACAP level measured in peripheral blood does not seem to be a biomarker reflecting parasympathetic activation in CM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.12949","type":"journal-article","created":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T05:13:26Z","timestamp":1474002806000},"page":"1448-1454","source":"Crossref","is-referenced-by-count":35,"title":["No Change in Interictal PACAP Levels in Peripheral Blood in Women With Chronic Migraine"],"prefix":"10.1111","volume":"56","author":[{"given":"Eva","family":"Cernuda\u2010Moroll\u00f3n","sequence":"first","affiliation":[{"name":"Neuroscience Area, Service of Neurology University Hospital Central de Asturias, Oviedo and Ineuropa Oviedo (E. Cernuda\u2010Moroll\u00f3n, N. Riesco, E. Serrano\u2010Pertierra, C. Garc\u00eda\u2010Cabo, and J. Pascual)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Riesco","sequence":"additional","affiliation":[{"name":"Neuroscience Area, Service of Neurology University Hospital Central de Asturias, Oviedo and Ineuropa Oviedo (E. Cernuda\u2010Moroll\u00f3n, N. Riesco, E. Serrano\u2010Pertierra, C. Garc\u00eda\u2010Cabo, and J. Pascual)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Mart\u00ednez\u2010Camblor","sequence":"additional","affiliation":[{"name":"Oficina de Investigaci\u00f3n Biosanitaria OIB, Oviedo, Asturias, Spain Universidad Aut\u00f3noma de Chile Santiago, Chile (P. Mart\u00ednez\u2010Camblor)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Serrano\u2010Pertierra","sequence":"additional","affiliation":[{"name":"Neuroscience Area, Service of Neurology University Hospital Central de Asturias, Oviedo and Ineuropa Oviedo (E. Cernuda\u2010Moroll\u00f3n, N. Riesco, E. Serrano\u2010Pertierra, C. Garc\u00eda\u2010Cabo, and J. Pascual)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Garc\u00eda\u2010Cabo","sequence":"additional","affiliation":[{"name":"Neuroscience Area, Service of Neurology University Hospital Central de Asturias, Oviedo and Ineuropa Oviedo (E. Cernuda\u2010Moroll\u00f3n, N. Riesco, E. Serrano\u2010Pertierra, C. Garc\u00eda\u2010Cabo, and J. Pascual)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Pascual","sequence":"additional","affiliation":[{"name":"Neuroscience Area, Service of Neurology University Hospital Central de Asturias, Oviedo and Ineuropa Oviedo (E. Cernuda\u2010Moroll\u00f3n, N. Riesco, E. Serrano\u2010Pertierra, C. Garc\u00eda\u2010Cabo, and J. Pascual)"},{"name":"University Hospital Marqu\u00e9s de Valdecilla and IDIVAL Santander Spain (J. 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