{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:13:52Z","timestamp":1783178032428,"version":"3.54.6"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T00:00:00Z","timestamp":1482278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To perform a literature review of the epidemiology, clinical presentation, diagnostic evaluation, and clinical course of occipital condyle syndrome, including a new case report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Occipital condyle syndrome (OCS) is a rare clinical syndrome, consisting of unilateral occipital headache accompanied by ipsilateral hypoglossal palsy. This headache typically radiates to the temporal region, and is triggered by contralateral head rotation. It is usually associated with skull base metastasis, often unrevealed in basic neuroimaging studies. OCS might be the first manifestation of malignancy, and its unfamiliarity can lead to a delay in the diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a systematic literature review using PubMed and Embase for OCS, along with a new case report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 35 cases (mean age 59 years, range 25\u201077), 24 (70%) men, presented typical unilateral headache followed by ipsilateral hypoglossal palsy from 0 to 150 days after headache presentation. In 16 patients (46%), initial neuroimaging studies were normal. OCS was due to skull base metastasis in 32 cases (91%). In 18 patients (51%), OCS was the first symptom of disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OCS represents a warning sign and requires an exhaustive search for underlying neoplasm. An appropriate clinical evaluation can lead to an earlier diagnosis in patients with consistent headache.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13008","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T02:12:48Z","timestamp":1482286368000},"page":"699-708","source":"Crossref","is-referenced-by-count":19,"title":["Occipital Condyle Syndrome: A Red Flag for Malignancy. Comprehensive Literature Review and New Case Report"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8926-1287","authenticated-orcid":false,"given":"Jorge","family":"Rodr\u00edguez\u2010Pardo","sequence":"first","affiliation":[{"name":"La Paz University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Lara\u2010Lara","sequence":"additional","affiliation":[{"name":"La Paz University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja E.","family":"Sanz\u2010Cuesta","sequence":"additional","affiliation":[{"name":"La Paz University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Fuentes","sequence":"additional","affiliation":[{"name":"La Paz University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Exuperio","family":"D\u00edez\u2010Tejedor","sequence":"additional","affiliation":[{"name":"La Paz University Hospital Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.31.5.530"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-004-8099-0"},{"key":"e_1_2_8_4_1","first-page":"293","article-title":"S\u00edndrome del c\u00f3ndilo occipital: Presentaci\u00f3n de un caso","volume":"4","author":"Pascual J","year":"1989","journal-title":"Neurologia."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1998.3804308.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2002.02032.x"},{"key":"e_1_2_8_7_1","first-page":"31","article-title":"Par\u00e1lisis aislada del nervio hipogloso debida a met\u00e1stasis de la base del cr\u00e1neo","volume":"15","author":"Romero M","year":"2000","journal-title":"Neurolog\u00eda."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1673.2001.00977.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2006.01466.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7753(07)72575-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100007356"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-008-0154-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.08.2008.0636"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.68686"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.praneu.2010.06.002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2012.00053"},{"key":"e_1_2_8_17_1","first-page":"56","article-title":"Skull base leiomyosarcoma metastasis manifesting itself as occipital condyle syndrome. A case report","volume":"0","author":"Stepanyan MA","year":"2013","journal-title":"Opuholi Golovy \u0160ei."},{"key":"e_1_2_8_18_1","first-page":"1","article-title":"Occipital condyle syndrome in a young male: A rare presentation of cranio\u2010vertebral tuberculosis","volume":"8","author":"Neera C","year":"2014","journal-title":"J Clin Diagn Res."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2015.04.011"},{"key":"e_1_2_8_20_1","first-page":"11","article-title":"Occipital condyle syndrome as an initial presentation of lung cancer: A case report","volume":"24","author":"Liu MT","year":"2015","journal-title":"Acta Neurol Taiwan."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-004-2617-5"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2013.11.005"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.17.5.9308105"},{"key":"e_1_2_8_24_1","first-page":"71","article-title":"Metastatic skull tumours: Diagnosis and management","volume":"4","author":"Mitsuya K","year":"2014","journal-title":"Eur Assoc NeuroOncol Mag."}],"container-title":["Headache: The Journal of Head and Face Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhead.13008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhead.13008","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/head.13008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T12:12:38Z","timestamp":1762085558000},"score":1,"resource":{"primary":{"URL":"https:\/\/headachejournal.onlinelibrary.wiley.com\/doi\/10.1111\/head.13008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,21]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/head.13008"],"URL":"https:\/\/doi.org\/10.1111\/head.13008","archive":["Portico"],"relation":{},"ISSN":["0017-8748","1526-4610"],"issn-type":[{"value":"0017-8748","type":"print"},{"value":"1526-4610","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,21]]}}}