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Participants completed surveys assessing chronic migraine (meeting criteria for migraine with \u226515 headache days in the past month), severe migraine disability (Migraine Disability Assessment Scale score\u2009\u2265\u200921), and modifiable psychological factors (depressive symptoms [Patient Health Questionnaire\u20109], anxious symptoms [Generalized Anxiety Disorder\u20107], Pain Catastrophizing Scale and Headache Specific Locus of Control). Logistic regression evaluated relationships between modifiable psychological factors and chronic migraine and severe migraine disability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 90 eligible participants the mean age was 45.0 (SD\u2009=\u200912.4); 84.8% were women. One\u2010third (36.0%) met study criteria for chronic migraine; half of participants (51.5%) reported severe migraine\u2010related disability. Higher depressive symptoms (OR\u2009=\u20091.99, 95% CI\u2009=\u20091.11, 3.55) and chance HSLC (OR\u2009=\u20091.85, 95% CI\u2009=\u20091.13, 1.43) were associated with chronic migraine. Higher depressive symptoms (OR\u2009=\u20093.54, 95%CI\u2009=\u20091.49, 8.41), anxiety symptoms (OR\u2009=\u20093.65, 95% CI\u2009=\u20091.65, 8.06), and pain catastrophizing (OR\u2009=\u20091.95, 95% CI\u2009=\u20091.14, 3.35), were associated with severe migraine\u2010related disability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Psychiatric symptoms and pain catastrophizing were strongly associated with severe migraine\u2010related disability. Depression and chance locus of control were associated with chronic migraine. This study supports the need for longitudinal observational studies to evaluate the relationships among naturalistic variation in psychological factors, migraine\u2010related disability, and migraine chronification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13021","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T03:59:37Z","timestamp":1485835177000},"page":"593-604","source":"Crossref","is-referenced-by-count":100,"title":["Psychological Factors Associated With Chronic Migraine and Severe Migraine\u2010Related Disability: An Observational Study in a Tertiary Headache Center"],"prefix":"10.1111","volume":"57","author":[{"given":"Elizabeth K.","family":"Seng","sequence":"first","affiliation":[{"name":"Ferkauf Graduate School of Psychology Yeshiva University Bronx NY USA"},{"name":"Albert Einstein College of Medicine Bronx NY USA"},{"name":"Montefiore Medical Center Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn C.","family":"Buse","sequence":"additional","affiliation":[{"name":"Ferkauf Graduate School of Psychology Yeshiva University Bronx NY USA"},{"name":"Albert Einstein College of Medicine Bronx NY USA"},{"name":"Montefiore Medical Center Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaclyn E.","family":"Klepper","sequence":"additional","affiliation":[{"name":"Ferkauf Graduate School of Psychology Yeshiva University Bronx NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"J. 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