{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:25:01Z","timestamp":1785835501132,"version":"3.56.0"},"reference-count":75,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,13]],"date-time":"2017-03-13T00:00:00Z","timestamp":1489363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Headache"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To review current neuromodulation treatments available for migraine therapy, both in the acute and preventive setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The published literature was reviewed for studies reporting the effects of different neuromodulation strategies in migraine with and without aura. The use of non\u2010invasive: single pulse transcranial magnetic stimulation, non\u2010invasive vagal nerve stimulation, supraorbital nerve stimulation, and transcranial direct current stimulation, as well as invasive methods such as occipital nerve stimulation and sphenopalatine ganglion stimulation, are assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The available evidence shows that non\u2010invasive techniques represent promising treatment strategies, whereas an invasive approach should only be used where patients are refractory to other preventives, including non\u2010invasive methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Neuromodulation is emerging as an exciting approach to migraine therapy, especially in the context of failure of commonly used medicines or for patients who do not tolerate common side effects. More studies with appropriate blinding strategies are needed to confirm the results of these new treatment opportunities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/head.13069","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T16:05:23Z","timestamp":1489507523000},"page":"685-691","source":"Crossref","is-referenced-by-count":59,"title":["An Update on Non\u2010Pharmacological Neuromodulation for the Acute and Preventive Treatment of Migraine"],"prefix":"10.1111","volume":"57","author":[{"given":"Francesca","family":"Puledda","sequence":"first","affiliation":[{"name":"Department of Basic and Clinical Neuroscience Institute of Psychiatry, Psychology and Neuroscience King's College (F. 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